V4302

DATASHEET

Host: Mouse

Target Protein: Renin

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 5972

Purification: affinity purified by Protein A

Storage Buffer: PBS (pH7.4).

Storage: Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008].

Size: 1mg

Concentration: Lot Dependent

Applications: ELISA(1:500-1000)
LFA(N/A)

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.