bs-0174R-Cy5 [Conjugated Primary Antibody]
Estrogen Receptor alpha + beta Antibody, Cy5 Conjugated
www.biossusa.com
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DATASHEET

Host: Rabbit

Target Protein: Estrogen Receptor alpha + beta

Immunogen Range: 201-300/595


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2099, 2100

Source: KLH conjugated synthetic peptide derived from human Estradiol Receptor alpha + beta

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The estrogen receptor (ER) is a 66 kDa protein that mediates the actions of estrogens in estrogen responsive tissues. It is a member of a large superfamily of nuclear hormone receptors that function as ligand activated transcription factors. The ER gene consists of more than 140 kb of genomic DNA divided into 8 exons. These translate into a protein with six functionally discrete domains, labeled A through F. A second form of the estrogen receptor, ER beta has recently been described. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti estrogen (e.g. tamoxifen) therapy.

Conjugation: Cy5

Excitation/ Emission: 625,650nm/670nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 66


Cross Reactive Species: Human
Rat

Predicted Cross Reactive Species: Mouse
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Li, Fei, et al. "Antiosteoporotic activity of echinacoside in ovariectomized rats." Phytomedicine (2013).Read more>>
  • Jia M et al. A platform for primary tumor origin identification of circulating tumor cells via antibody cocktail-based in vivo capture and specific aptamer-based multicolor fluorescence imaging strategy. Analytica Chimica Acta.2019 July.Read more>>
  • Francesca Salamanna. et al. Development and characterization of a novel human 3D model of bone metastasis from breast carcinoma in vitro cultured. Bone. 2021 Feb;143:115773Read more>>
  • Wei W. et al. Apigenin, a Single Active Component of Herbal Extract, Alleviates Xerostomia <i>via</i> ER_-Mediated Upregulation of AQP5 Activation.. Front Pharmacol. 2022 Feb;13:818116-818116Read more>>
  • Yu Tang. et al. hUMSCs Restore Uterine Function by Inhibiting Endometrial Fibrosis via Regulation of the MMP-9/TIMP-1 Ratio in CDDP-Induced Injury Rats. STEM CELLS INT. 2023;2023:8014052Read more>>
  • Karaca Efe. et al. Naringenin stimulates aromatase expression and alleviates the clinical and histopathological findings of experimental autoimmune encephalomyelitis in C57bl6 mice. HISTOCHEM CELL BIOL. 2023 Jun;:1-14Read more>>
  • Tian Yanpeng. et al. Alternative Biological Material for Tissue Engineering of the Vagina: Porcine-Derived Acellular Vaginal Matrix. Tissue Engineering and Regenerative Medicine. 2023 Nov;:1-14Read more>>
VALIDATION IMAGES