bs-0178R [Primary Antibody]
Nurr1 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Nurr1

Specificity: 90% sequence similarity with Nuclear receptor subfamily 4 group A member 3

Immunogen Range: 301-400/598


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4929

Source: KLH conjugated synthetic peptide derived from human Nurr1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Nuclear receptor and transcription factor; plays a role in development and maintenance of neurons synthesizing the neurotransmitter dopamine This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 67


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Cow
Pig
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Qiu Qian. et al. Propofol protects H9C2 cells against hypoxia/reoxygenation injury through miR?449a and NR4A2. Exp Ther Med. 2021 Oct;22(4):1-11Read more>>
  • Lijun Dai. et al. The Distribution, Expression Patterns and Functional Analysis of NR1D1 and NR4A2 in the Reproductive Axis Tissues of the Male Tianzhu White Yak. Animals-Basel. 2021 Nov;11(11):3117Read more>>
VALIDATION IMAGES

Frozen mouse hippocampus tissue labeled with Anti-Nurr1 Polyclonal Antibody, Unconjugated (bs-0178R) followed by conjugation to the secondary antibody


Lane 1: Human Hela cell lysates; Lane 2: Human U-87MG cell lysates; Lane 3: Human MCF-7 cell lysates; Lane 4: Human HepG2 cell lysates; Lane 5: Human Raji cell lysates; Lane 6: Human U251 cell lysates probed with Nurr1 Polyclonal Antibody, Unconjugated (bs-0178R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.