bs-0182R-A555 [Conjugated Primary Antibody]
PTP1B Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated
www.biossusa.com
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DATASHEET

Host: Rabbit

Target Protein: PTP1B

Immunogen Range: 1-100/435


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5770

Swiss Prot: P18031

Source: KLH conjugated synthetic peptide derived from human PTP-1B

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Conjugation: ALEXA FLUOR® 555

Excitation/ Emission: 555nm/580nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 48


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Cow
Pig
Horse
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yang P et al. Loss of CD36 impairs hepatic insulin signaling by enhancing the interaction of PTP1B with IR. FASEB J. 2020 Apr;34(4):5658-5672.Read more>>
  • Lvjing Luo. et al. miR-124-3p regulates the involvement of Ptpn1 in testicular development and spermatogenesis in mouse. GENE. 2024 Jan;893:147967Read more>>
VALIDATION IMAGES