Target Protein: PTP1B
Immunogen Range: 13-65/435
Entrez Gene: 5770
Swiss Prot: P18031
Source: KLH conjugated synthetic peptide derived from human PTP-1B
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin.
Storage Condition: Store at 4°C for 12 months.
Background: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.