bs-0246R-A647 [Conjugated Primary Antibody]
CRF Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]

Host: Rabbit

Target Protein: CRF

Immunogen Range: 185-196/196

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1392

Swiss Prot: P06850

Source: KLH conjugated synthetic peptide derived from human CRF

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.


Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010].

Conjugation: ALEXA FLUOR® 647

Excitation/ Emission: 650nm/665nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)

Predicted Molecular Weight: 21-Apr

Cross Reactive Species: Human

Predicted Cross Reactive Species: Dog
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

  • Balan, Irina, et al. "Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity." Brain, Behavior, and Immunity(2017).Read more>>
  • Balan et al. The GABAA Receptor α2 Subunit Activates a Neuronal TLR4 Signal in the Ventral Tegmental Area that Regulates Alcohol and Nicotine Abuse. (2018) Brain.Sci. 8 Read more>>
  • CONTE RAFAEL. et al. Effects of moderate alcohol consumption on behavior and neural systems of Wistar rats. AN ACAD BRAS CIENC. 2022 Jul;94Read more>>
  • Steven L. Bernstein. et al. Neuroprotection and Neuroregeneration Strategies Using the rNAION Model: Theory, Histology, Problems, Results and Analytical Approaches. INT J MOL SCI. 2022 Jan;23(24):15604Read more>>
  • Roland Csurgyk. et al. Expression of Wilms-tumor 1 antigen, vimentin and corticotropin releasing factor in human kidney with focal segmental glomerulosclerosis and effect of oxidative stress on these markers in HEK 293 cells. KIDNEY BLOOD PRESS R. 2022 Dec;:1Read more>>