bs-0246R-Cy3 [Conjugated Primary Antibody]
CRF Polyclonal Antibody, Cy3 Conjugated
www.biossusa.com
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Host: Rabbit

Target Protein: CRF

Immunogen Range: 185-196/196

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1392

Swiss Prot: P06850

Source: KLH conjugated synthetic peptide derived from human CRF

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

Storage Condition: Store at 4°C for 12 months.

Background: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010].

Conjugation: Cy3

Excitation/ Emission: 512,550nm/570,615nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Dog
Pig
Chicken
Rabbit
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Balan, Irina, et al. "Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity." Brain, Behavior, and Immunity(2017).Read more>>
  • Balan et al. The GABAA Receptor α2 Subunit Activates a Neuronal TLR4 Signal in the Ventral Tegmental Area that Regulates Alcohol and Nicotine Abuse. (2018) Brain.Sci. 8 Read more>>