DATASHEET
Host:
Rabbit
Target Protein:
MTLC
Immunogen Range:
21-100/235
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
80177
Swiss Prot:
Q8N699
Source:
KLH conjugated synthetic peptide derived from human MTLC
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).
PRODUCT SPECIFIC PUBLICATIONS
- Li Y et al. Yin Yang Gong Ji pill is an ancient formula with antitumor activity against hepatoma cells J Ethnopharmacol. 2019 Oct 3;248:112267.Read more>>
- "Zhang C et al. MiR-429 regulates rat liver regeneration and hepatocyte proliferation by targeting JUN/MYC/BCL2/CCND1 signaling pathway.Cell Signal. 2018 Oct;50:80-89."Read more>>
VALIDATION IMAGES
Mouse brain lysates probed with MTLC Polyclonal Antibody, unconjugated (bs-0334R) at 1:300 overnight at 4°C followed by a conjugated secondary antibody at 1:10000 for 60 minutes at 37°C.
Formalin-fixed and paraffin embedded: human colon carcinoma labeled with Anti-MTLC Polyclonal Antibody (bs-0334R), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining