bs-0368G [Secondary Antibody]
Goat Anti-Mouse IgM Antibody (H+L)
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Goat

Clonality: Polyclonal

Isotype: IgM

Purification: Purified by Protein A.

Storage Buffer: Lyophilized

Storage: Store at -20°C for 12 months.

Background:

Immunoglobulin IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells.

Size: 1mg

Concentration: Determined by end user

Applications: WB(1:300-5000)
ELISA(1:500-1000)
FCM(1:20-100)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Cross Reactive Species: Mouse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
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  • Xin, Jige, et al. "Highly Efficient Generation of GGTA1 Biallelic Knockout Inbred Mini-Pigs with TALENs." PloS one 8.12 (2013): e84250.Read more>>
  • Geng, Zhaoxin, et al. "A route to low-cost nanoplasmonic biosensor integrated with optofluidic-portable platform." Sensors and Actuators B: Chemical (2014).Read more>>
  • Zhang, Xiaoru, et al. "Ultrasensitive Photoelectrochemical Immunoassay of Antibody against Tumor-associated Carbohydrate antigen Amplified by Functionalized Graphene Derivates and Enzymatic Biocatalytic Precipitation." Biosensors and Bioelectronics (2014).Read more>>
  • Zhang, Xiaoru, et al. "Ultrasensitive Photoelectrochemical Immunoassay of Antibody against Tumor-associated Carbohydrate antigen Amplified by Functionalized Graphene Derivates and Enzymatic Biocatalytic Precipitation." Biosensors and Bioelectronics (2014).Read more>>
  • Zhang, Yani, et al. "Selection of the Inducer for the Differentiation of Chicken Embryonic Stem Cells into Male Germ Cells In Vitro." PloS one 11.10 (2016): e0164664.Read more>>
  • Jiang, P., et al. "Eryptosis as an Underlying Mechanism in Systemic Lupus Erythematosus-Related Anemia." Cellular Physiology and Biochemistry 40.6 (2016): 1391-1400.Read more>>
  • Zhang, Minghui, et al. "Annexin A2 Positively Regulates Milk Synthesis and Proliferation of Bovine Mammary Epithelial Cells through the mTOR Signaling Pathway." Journal of Cellular Physiology (2017).Read more>>
  • Lu et al. Matrine reduces the proliferation of A549 cells via the p53/p21/PCNA/eIF4E signaling pathway. (2017) Mol.Med.Re. 15:2415-2422Read more>>
  • Aboelenain et al. Status of autophagy, lysosome activity and apoptosis during corpus luteum regression in cattle. (2015) J.Reprod.De. 61:229-36Read more>>
  • Li et al. Endogenous ceramide contributes to the transcytosis of oxLDL across endothelial cells and promotes its subendothelial retention in vascular wall. (2014) Oxid.Med.Cell.Longev. 2014:823071Read more>>
  • Guan et al. Promotion of cell migration by neural cell adhesion molecule (NCAM) is enhanced by PSA in a polysialyltransferase-specific manner. (2015) PLoS.One. 10:e0124237Read more>>
  • Zhang et al. Selection of the Inducer for the Differentiation of Chicken Embryonic Stem Cells into Male Germ Cells In Vitro. (2016) PLoS.One. 11:e0164664Read more>>
  • Peng et al. Overexpressing modified human TRβ1 suppresses the proliferation of breast cancer MDA-MB-468 cells. (2018) Oncol.Lett. 16:785-792Read more>>
  • Zhang,et al.The Role of Tumor-Associated Ingredients in Serum on Antitumor Immunity.(2017) Drug Design Development and Therapy. 1:.Read more>>
  • Yu M et al. Amino acids stimulate glycyl-tRNA synthetase nuclear localization for mammalian target of rapamycin expression in bovine mammary epithelial cells.(2018)J. Cell. Physiol. Read more>>
  • Wang et al. Characteristics of repaglinide and its mechanism of action on insulin secretion in patients with newly diagnosed type-2 diabetes mellitus. (2018) Medicine.(Baltimore). 97:e12476Read more>>
  • Wang L et al. Pericentrin expression in pancreatic β cells is associated impaired glucose tolerance. Am J Transl Res. 2019 Apr 15;11(4):2257-2268. Read more>>
  • Ding J et al. The Effect of α-Synuclein and Tau in Methamphetamine Induced Neurotoxicity in Vivo and in Vitro. Toxicol Lett. 2020 Feb 1;319:213-224.Read more>>
  • Jiang C et al. Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation. Cell Stress Chaperones. 2020 May;25(3):395-406.Read more>>
  • Huang Y et al. Nondestructive Identification of Rare Trophoblastic Cells by Endoplasmic Reticulum Staining for Noninvasive Prenatal Testing of Monogenic Diseases. Adv Sci (Weinh). 2020 Feb 13;7(7):1903354.Read more>>
  • Ranran Liet al. Downregulation of the CB1-Mediated Endocannabinoid Signaling Underlies D-Galactose-Induced Memory Impairment. Front Mol Neurosci. 2020 Jul 28;13:130.Read more>>
  • Xuesong Wanget al. LncRNA NEAT1 Regulates 5-Fu Sensitivity, Apoptosis and Invasion in Colorectal Cancer Through the MiR-150-5p/CPSF4 Axis. Onco Targets Ther. 2020 Jul 1;13:6373-6383.Read more>>
  • Yitian Du. et al. Engineered Microglia Potentiate the Action of Drugs against Glioma Through Extracellular Vesicles and Tunneling Nanotubes. 2021 Feb 28Read more>>
  • Hongwei Duan. et al. Dihydrotestosterone regulates oestrogen secretion, oestrogen receptor expression, and apoptosis in granulosa cells during antral follicle development. J Steroid Biochem. 2021 Mar;207:105819Read more>>
  • Fan Li. et al. PHD3 mediates denervation skeletal muscle atrophy through Nf\B signal pathway. Faseb J. 2021 Apr;35(4):e21444Read more>>
  • Jianqing Zhao. et al. A Novel Oral Rabies Vaccine Enhances the Immunogenicity through Increasing Dendritic Cells Activation and Germinal Center Formation by Expressing U-OMP19 in a Mouse Model. 2021 Apr 27Read more>>
  • Yao Gao. et al. Melatonin attenuates hepatic ischemia-reperfusion injury in rats by inhibiting NF-B signaling pathway. Hepatob Pancreat Dis. 2021 ApRead more>>
  • Xueli Bai. et al. Regulatory role of methionine enkephalin in myeloid-derived suppressor cells and macrophages in human cutaneous squamous cell carcinoma. Int Immunopharmacol. 2021 Oct;99:107996Read more>>
  • Kexin Zhu. et al. Characterization and protective activity of monoclonal antibodies directed against Fe (3+) ABC transporter substrate-binding protein of Glaesserella parasuis. Vet Res. 2021 Dec;52(1):1-1Read more>>
  • Yuan SJ. et al. Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.. Int J Pharmaceut. 2021 Jul;606:120872-120872Read more>>
  • Yue SU. et al. Exosomes derived from placental trophoblast cells regulate endometrial epithelial receptivity in dairy cows during pregnancy. 2021 Oct 22Read more>>
  • Li-Ming Yu. et al. Activation of PKG-CREB-KLF15 by melatonin attenuates Angiotensin II-induced vulnerability to atrial fibrillation via enhancing branched-chain amino acids catabolism. Free Radical Bio Med. 2021 DecRead more>>
  • Chen Duan. et al. trans 10, cis 12, but Not cis 9, trans 11 Conjugated Linoleic Acid Isomer Enhances Exercise Endurance by Increasing Oxidative Skeletal Muscle Fiber Type via Toll-like Receptor 4 Signaling in Mice. J Agr Food Chem. 2021;69(51):15636C15648Read more>>
  • Peng Gu. et al. Suppression of CDCA3 inhibits prostate cancer progression via NF?B/cyclin D1 signaling inactivation and p21 accumulation. Oncol Rep. 2022 Feb;47(2):1-1Read more>>
  • Zhiyong Shen. et al. GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer. Cancer Lett. 2022 May;534:215617Read more>>
  • Peng Xi. et al. The mechanism of dioscin preventing lung cancer based on network pharmacology and experimental validation. J Ethnopharmacol. 2022 Mar;:115138Read more>>
  • Xusheng Du. et al. Marek's Disease Virus and Reticuloendotheliosis Virus Coinfection Enhances Viral Replication and Alters Cellular Protein Profiles. Front Vet Sci. 2022; 9: 854007Read more>>
  • Zhu Kunming. et al. Effect of Sirtuin-1 and Wnt/_-Catenin Signaling Pathway in Rat Model of Spinal Cord Injury. Comput Math Method M. 2022;2022:1799607Read more>>
  • Zi Liang. et al. _-Arrestin 2 acts an adaptor protein that facilitates viral replication in silkworm. INT J BIOL MACROMOL. Int J Biol Macromol. 2022 May;208:1009Read more>>
  • Hongtao Liu. et al. Antiviral Effects of ABMA and DABMA against Influenza Virus In Vitro and In Vivo via Regulating the Endolysosomal Pathway and Autophagy. INT J MOL SCI. Int J Mol Sci. 2022 Jan;23(7):394Read more>>
  • Xuebing Chen. et al. Chronic exposure to polyvinyl chloride microplastics induces liver injury and gut microbiota dysbiosis based on the integration of liver transcriptome profiles and full-length 16S rRNA sequencing data. SCI TOTAL ENVIRON. 2022 May;:155984Read more>>
  • Wei Qin. et al. CAF-derived exosomes transmitted Gremlin-1 promotes cancer progression and decreases the sensitivity of hepatoma cells to sorafenib. MOL CARCINOGEN. 2022 May 31Read more>>
  • Hongge Wang. et al. Mechanism of Erastin-Induced Ferroptosis in MDA-MB-231 Human Breast Cancer Cells: Evidence for a Critical Role of Protein Disulfide Isomerase | Molecular and Cellular Biology. MOL CELL BIOL. 2022 MayRead more>>
  • Shou Di-Wen. et al. Panax notoginseng Alleviates Sepsis-Induced Acute Kidney Injury by Reducing Inflammation in Rats. EVID-BASED COMPL ALT. 2022;2022:9742169Read more>>
  • Weixu Feng. et al. Nucleocapsid protein of SARS-CoV-2 is a potential target for developing new generation of vaccine. J CLIN LAB ANAL. 2022 May 09Read more>>
  • Luo, Lu. et al. Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NF_B/NLRP3 signaling pathway in cerebral ischemic mice. J NEUROINFLAMM. 2022 Dec;19(1):1-27Read more>>
  • Jin Wang. et al. Irisin protects against sepsis-associated encephalopathy by suppressing ferroptosis via activation of the Nrf2/GPX4 signal axis. FREE RADICAL BIO MED. 2022 Jul;187:171Read more>>
  • Guangning Kou. et al. Sesamin Activates Skeletal Muscle FNDC5 Expression and Increases Irisin Secretion via the SIRT1 Signaling Pathway. J AGR FOOD CHEM. 2022;XXXX(XXX):XXX-XXXRead more>>
  • Qi Wang. et al. Syce1 and Syce3 regulate testosterone and dihydrotestosterone synthesis via steroidogenic pathways in mouse Sertoli and Leydig cells. J STEROID BIOCHEM. 2022 Oct;223:106135Read more>>