bs-0379R [Primary Antibody]
IL-6 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: IL-6

Immunogen Range: 101-150/211


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 16193

Swiss Prot: P08505

Source: KLH conjugated synthetic peptide derived from mouse IL-6

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 23


Cross Reactive Species: Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Mohamed, Nesma Sultan, et al. "Impact of Three Different Mouthwashes on the Incidence of Gingival Overgrowth Induced by Cyclosporine-A; A Randomized Controlled Experimental Animal Study." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (2015).Read more>>
  • Li, Kang, et al. "CD14 knockdown reduces lipopolysaccharide-induced cell viability and expression of inflammation-associated genes in gastric cancer cells in vitro and in nude mouse xenografts." Molecular Medicine Reports.Read more>>
  • Chenna Narendra S, Chalise JP, Magnusson M, Uppugunduri S (2015) Local but Not Systemic Administration of Uridine Prevents Development of Antigen-Induced Arthritis. PLoS ONE 10(10): e0141863Read more>>
  • Elkabir, Mohammed Ali, et al. "Efficacy of azithromycin and metronidazole combined therapy on rats’ gingival overgrowth induced by cyclosporine-A: An experimental animal study." Journal of Oral Biology and Craniofacial Research (2016).Read more>>
  • Chang, Chih-Wei, et al. "Protective effects of the roots of Angelica sinensis on strenuous exercise-induced sports anemia in rats." Journal of Ethnopharmacology (2016).Read more>>
  • Hong, Yong-Han, et al. "Djulis (Chenopodium formosanum Koidz.) Water Extract and Its Bioactive Components Ameliorate Dermal Damage in UVB-Irradiated Skin Models." BioMed Research International 2016 (2016).Read more>>
  • Wang, Yun, et al. "Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats." Molecular Medicine Reports 15.2 (2017): 673-680.Read more>>
  • Chang et al. Interleukin-6 (IL-6) mediated the increased contraction of distal colon in streptozotocin-induced diabetes in rats via IL-6 receptor pathway. (2015) Int.J.Clin.Exp.Patho. 8:4514-24Read more>>
  • Kemmler et al. Exposure to 100% Oxygen Abolishes the Impairment of Fracture Healing after Thoracic Trauma. (2015) PLoS.On. 10:e0131194Read more>>
  • Ehrnthaller et al. C5aR inhibition in the early inflammatory phase does not affect bone regeneration in a model of uneventful fracture healing. (2016) Eur.J.Med.Res. 21:42Read more>>
  • Hong et al. Djulis (Chenopodium formosanumKoidz.) Water Extract and Its Bioactive Components Ameliorate Dermal Damage in UVB-Irradiated Skin Models. (2016) Biomed.Res.Int. 2016:7368797Read more>>
  • Ding et al. Porphyromonas gingivalis , a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice. (2018) Immun.Ageing. 15:6Read more>>
  • Xi et al. Expressions of IL-6, TNF-α and NF-κB in the skin of Chinese brown frog (Rana dybowskii). (2017) Eur.J.Histochem. 61:2834Read more>>
  • Gao Y et al. Effect of splenectomy on attenuation of LPS-induced AKI through GTS-21-induced cholinergic anti-inflammatory pathway. Am J Transl Res. 2019 Apr 15;11(4):2540-2549. Read more>>
  • Hou DD et al. Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis. Int Immunopharmacol. 2019 Jun 7;74:105676.Read more>>
  • Qiu R et al. 20 (S)-Ginsenoside Rg3-loaded electrospun membranes to prevent postoperative peritoneal adhesion. Biomed Microdevices. 2019 Aug 14;21(4):78. Read more>>
  • Yamada H et al. LATE-ONSET ALZHEIMER'S DISEASE ANIMAL MODEL AND USES THEREOF. US Patent20190387723Read more>>
  • "Kang K et al. Dexmedetomidine protects against lipopolysaccharide-induced sepsis-associated acute kidney injury via an α7 nAChR-dependent pathway.Biomed Pharmacother. 2018 Oct;106:210-216. "Read more>>
  • Tianyang Huanget al. \Glucan ameliorates nonalcoholic steatohepatitis induced by methionine and choline\deficient diet in mice. J Food Biochem. 2020 Jul 26;e13408.Read more>>
  • Wang J et al. Effect of Asthma on Erectile Dysfunction in Rats as Determined by Biological Network AnalysisMed Sci Monit.2020 Dec 20;26:e927491.Read more>>
  • Yang Gao. et al. Mechanisms of Renal-Splenic Axis Involvement in Acute Kidney Injury Mediated by the 7nAChR-NF-B Signaling Pathway. 2020 Nov 03Read more>>
  • Chinthalapally V. Rao. et al. GSK3\ARC/Arg3.1 and GSK3\Wnt signaling axes trigger amyloid\ accumulation and neuroinflammation in middle\aged Shugoshin 1 mice. Aging Cell. 2020 Oct;19(10):e13221Read more>>
  • Sheng Deng. et al. Xuefu Zhuyu decoction improves asthma-induced asthenozoospermia based on network pharmacology and in vivo experiment. 2021 Aug 1Read more>>
  • Yizi Zhang. et al. Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice. Biomed Pharmacother. 2021 Dec;144:112268Read more>>
  • Gul Fatma Yarim. et al. Nobiletin attenuates inflammation via modulating proinflammatory and antiinflammatory cytokine expressions in an autoimmune encephalomyelitis mouse model. Fitoterapia. 2022 Jan;156:105099Read more>>
  • Ruohong Chen. et al. Aged green tea reduces high-fat diet-induced fat accumulation and inflammation via activating the AMP-activated protein kinase signaling pathway. Food Nutr Res. 2022; 66: 10.29219/fnr.v66.7923Read more>>
  • Erdong Yuan. et al. Roles of Adinandra nitida (Theaceae) and camellianin A in HCl/ethanol-induced acute gastric ulcer in mice. FOOD SCI HUM WELL. 2022 Jul;11:1053Read more>>
  • Ho, Chia-Chi. et al. Aryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker. PART FIBRE TOXICOL. 2022 Dec;19(1):1-21Read more>>
  • Lingli Sun. et al. Extract of Jasminum grandiflorum L. alleviates CCl4-induced liver injury by decreasing inflammation, oxidative stress and hepatic CYP2E1 expression in mice. BIOMED PHARMACOTHER. 2022 Aug;152:113255Read more>>
  • Zhou, Taocheng. et al. Leonurine Alleviates Alcoholic Steatohepatitis Through the TLR4/NF-B Signalling Pathway. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy. 2022 Aug;:1-15Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded rat pancreas tissue labeled with Anti-IL-6 Polyclonal Antibody, Unconjugated (bs-0379R) followed by conjugation to the secondary antibody and DAB staining