bs-0395R [Primary Antibody]
CD133 Polyclonal Antibody
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Host: Rabbit

Target Protein: CD133

Immunogen Range: 751-848/865


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 8842

Swiss Prot: O43490

Source: KLH conjugated synthetic peptide derived from human CD133

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:500-2000)
Flow-Cyt(1μg/Test)

Predicted Molecular Weight: 95 kDa


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Rong et al. Biocompatibility of porcine small intestinal submucosa and rat endothelial progenitor cells in vitro. (2015) Int.J.Clin.Exp.Patho. 8:1282-91Read more>>
  • Castillo et al. Functional characteristics of cancer stem cells and their role in drug resistance of prostate cancer. (2014) Int.J.Onco. 45:985-94Read more>>
  • Tian et al. XAV939 inhibits the stemness and migration of neuroblastoma cancer stem cells via repression of tankyrase 1. (2014) Int.J.Onco. 45:121-8Read more>>
  • Hirota et al. High linear-energy-transfer radiation can overcome radioresistance of glioma stem-like cells to low linear-energy-transfer radiation. (2014) J.Radiat.Re. 55:75-83Read more>>
  • Wang et al. The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma. (2014) PLoS.On. 9:e97414Read more>>
  • Chen et al. Co-expression of CD133, CD44v6 and human tissue factor is associated with metastasis and poor prognosis in pancreatic carcinoma. (2014) Oncol.Re. 32:755-63Read more>>
  • Yang et al. Store-operated calcium entry-activated autophagy protects EPC proliferation via the CAMKK2-MTOR pathway in ox-LDL exposure. (2017) Autophagy. 13:82-98Read more>>
  • Wen et al. Striatal and Tegmental Neurons Code Critical Signals for Temporal-Difference Learning of State Value in Domestic Chicks. (2016) Front.Neurosci. 10:476Read more>>
  • Li H et al. siRNA‐mediated silencing of PAI‐1 gene acts as a promoter over the recanalization of endothelial progenitor cells in rats with venous thrombosis. J Cell Physiol. 2019 Apr 14. Read more>>
  • Heriansyah T et al. Polysaccharide peptide (PsP) Ganoderma lucidum: a potential inducer for vascular repair in type 2 diabetes mellitus model. Vasc Health Risk Manag. 2019 Oct 3;15:419-427. Read more>>
  • Hongxia Wei. et al. MRI tracing of ultrasmall superparamagnetic iron oxide nanoparticle?labeled endothelial progenitor cells for repairing atherosclerotic vessels in rabbits. Mol Med Rep. 2020 Oct;22(4):3327-3337Read more>>
  • Jiuping Gao. et al. Identification and characterization of a subpopulation of CD133 + cancer stem\like cells derived from SK-UT-1 cells. Cancer Cell Int. 2021 Dec;21(1):1-11Read more>>
  • Liang Guibin. et al. lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients. Oxid Med Cell Longev. 2022;2022:9369035Read more>>
  • Shang, Yuanyuan. et al. MiR-7-5p/KLF4 signaling inhibits stemness and radioresistance in colorectal cancer. CELL DEATH DISCOV. 2023 Feb;9(1):1-12Read more>>