bs-0427R [Primary Antibody]
P311 protein Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: P311 protein

Immunogen Range: 25-68/68


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 9315

Swiss Prot: Q16612

Source: KLH conjugated synthetic peptide derived from human P311

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 7.9


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Peng, Xu, et al. "Identification of ITGB4BP as a new interaction protein of P311." Life Sciences (2012).Read more>>
  • Li, Haisheng, et al. "P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression." Stem Cell Research & Therapy 7.1 (2016): 175.Read more>>
  • Yao, Zhihui, et al. "P311 accelerates skin wound reepithelialization by promoting epidermal stem cell migration through Rho A and Rac1 activation." Stem Cells and Development ja (2016).Read more>>
  • Yao, Zhihui, et al. "P311 promotes renal fibrosis via TGFβ1/Smad signaling." Scientific reports 5 (2015).Read more>>
  • Zhang et al. Role of P311 in interleukin-1α-induced epithelial to myofibroblast transition in kidney tubular epithelial cells. (2015) Ren.Fail. 37:1384-9Read more>>
  • Du Y et al. Butyrate alleviates diabetic kidney disease by mediating the miR\7a\5p/P311/TGF\1 pathway. FASEB J. 2020 Aug;34(8):10462-10475.Read more>>
  • Cheng-Cheng Deng. et al. Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases. Nat Commun. 2021 Jun;12(1):1-16Read more>>