bs-0434R-A488 [Conjugated Primary Antibody]
Factor 8 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Factor 8

Immunogen Range: 401-500/2258


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 302470

Swiss Prot: Q7TN96

Source: KLH conjugated synthetic peptide derived from rat factor VIII

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].

Conjugation: ALEXA FLUOR® 488

Excitation/ Emission: 490nm/525nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 267


Cross Reactive Species: Human
Mouse
Rat
Rabbit

Predicted Cross Reactive Species: Dog

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Lei, Jinghui, et al. "A simple and biosafe method for isolation of human umbilical vein endothelial cells." Analytical Biochemistry 508 (2016): 15-18.Read more>>
  • Yu, Jun-Min, et al. "Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction." Molecular Medicine Reports 12.5 (2015): 6718-6726.Read more>>
  • Song, Jian, Zonghuan Li, and Aixi Yu. "Effects of preserving different veins on flow-through flap survival: An experimental study." Experimental and therapeutic medicine 11.1 (2016): 318-324.Read more>>
  • Li, Zhe, et al. "Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43." Experimental and Therapeutic Medicine.Read more>>
  • Hu et al. Heparanase mediates vascular endothelial growth factor gene transcription in high-glucose human retinal microvascular endothelial cells. (2017) Mol.Vi. 23:579-587Read more>>
  • Li et al. Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation ofCx37,Cx40andCx43. (2018) Exp.Ther.Med. 15:1847-1854Read more>>
  • Ren et al. Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment. (2014) Drug.Des.Devel.Ther. 8:1527-38Read more>>
  • Dongmei He. et al. Cell membrane-coated biomimetic magnetic nanoparticles for the bio-specific extraction of components from Gualou Guizhi decoction exhibiting activities against oxygen-glucose deprivation/reperfusion injury. J Pharmaceut Biomed. 2022 Feb;209:114528Read more>>
  • Liu, Chengli. et al. GLP-1R Agonist Exendin-4 Protects Against Hemorrhagic Transformation Induced by rtPA After Ischemic Stroke via the Wnt/_-Catenin Signaling Pathway. Mol Neurobiol. 2022 Mar;:1-16Read more>>
  • Weijie Jiao. et al. Construction and Evaluation of Small-Diameter Bioartificial Arteries Based on a Combined-Mold Technology. POLYMERS-BASEL. 2022 Jan;14(15):3089Read more>>