bs-0463R [Primary Antibody]
MMP-1 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: MMP-1

Immunogen Range: 401-464/464

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 300339

Source: KLH conjugated synthetic peptide derived from rat MMP1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

Storage: Store at -20°C for 12 months..

Background:

The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.

Size: 100ul

Concentration: 1ug/ul

Predicted Molecular Weight: 27/41/54

Cross Reactive Species: Human
Mouse
Rat
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Luo, Yang, et al. "The inhibitory effect of salmon calcitonin on intervertebral disc degeneration in an ovariectomized rat model." European Spine Journal (2014): 1-11.Read more>>
  • Mohamed, Nesma Sultan, et al. "Impact of Three Different Mouthwashes on the Incidence of Gingival Overgrowth Induced by Cyclosporine-A; A Randomized Controlled Experimental Animal Study." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (2015).Read more>>
  • Elkabir, Mohammed Ali, et al. "Efficacy of azithromycin and metronidazole combined therapy on rats’ gingival overgrowth induced by cyclosporine-A: An experimental animal study." Journal of Oral Biology and Craniofacial Research (2016).Read more>>
  • Ding, Feng, et al. "Osteopontin stimulates matrix metalloproteinase expression through the nuclear factor-κB signaling pathway in rat temporomandibular joint and condylar chondrocytes." Am J Transl Res 9.2 (2017): 316-329.Read more>>
  • Song, Huiping, et al. "Effects of alendronateon lumbar intervertebral disc degeneration with bone loss in ovariectomized rats." The Spine Journal (2017).Read more>>
  • Jiang et al. Effect of calcitonin pretreatment on naturally occurring intervertebral disc degeneration in guinea pig. (2015) Int.J.Clin.Exp.Me. 8:10367-79Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded rat colitis labeled with Anti-MMP-1 Polyclonal Antibody, Unconjugated (bs-0463R) at 1:200 followed by conjugation to the secondary antibody and DAB staining\n