bs-0581R [Primary Antibody]
IL-4 Polyclonal Antibody
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Host: Rabbit

Target Protein: IL-4

Immunogen Range: 105-140/140


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 16189

Swiss Prot: P07750

Source: KLH conjugated synthetic peptide derived from mouse IL-4

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

Size: 100µL

Concentration: 1ug/ul

Applications: IHC-P(1:200-400)
IF(IHC-P)(1:50-200)

Predicted Molecular Weight: 16


Cross Reactive Species: Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
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  • Jie, Guo, et al. "Expression of interleukin-17 in autoimmune dacryoadenitis in MRL/lpr mice." Current eye research 35.10 (2010): 865-871.Read more>>
  • Guo, Jie, Jiang Qian, and Rui Zhang. "Histopathology and immunohistochemical profile in idiopathic dacryoadenitis." Current eye research 37.5 (2012): 365-371.Read more>>
  • Qin et al. Intrapleural delivery of MSCs attenuates acute lung injury by paracrine/endocrine mechanism. (2012) J.Cell.Mol.Med. 16:2745-53Read more>>
  • Xiong Y et al. Functions of T-cell subsets and their related cytokines in the pathological processes of autoimmune encephalomyelitic mice.(2018) Int J Clin Exp Pathol;11(10):4817-4826.Read more>>
  • Hou DD et al. Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis. Int Immunopharmacol. 2019 Jun 7;74:105676.Read more>>
  • Li G et al. Effects of combined treatment with PD‑L1 Ig and CD40L mAb on immune tolerance in the CBA/J x DBA/2 mouse model. Molecular Medicine Reports, 2020, 21, 1789-1798.Read more>>
  • Luo Q et al. Iron Overload Resulting from the Chronic Oral Administration of Ferric Citrate Impairs Intestinal Immune and Barrier in Mice. Biol Trace Elem Res. 2020 May 28.Read more>>
  • Fei W et al. The effects of aqueous extract of Maca on energy metabolism and immunoregulation. Eur J Med Res. 2020 Jun 29;25(1):24.Read more>>
  • Yang T et al. Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis. Life Sci.2020 Dec 16;266:118903.Read more>>
  • Qingqing Chen. et al. Coptis chinensis Franch polysaccharides provide a dynamically regulation on intestinal microenvironment, based on the intestinal flora and mucosal immunity. J Ethnopharmacol. 2021 Mar;267:113542Read more>>
  • Xinran Li. et al. Fumonisins B1 exposure triggers intestinal tract injury via activating nuclear xenobiotic receptors and attracting inflammation response. Environ Pollut. 2020 Dec;267:115461Read more>>
  • Chan Mo. et al. Mutual antagonism between indoleamine 2,3-dioxygenase 1 and nuclear factor E2-related factor 2 regulates the maturation status of DCs in liver fibrosis. Free Radical Bio Med. 2020 Nov;160:178Read more>>
  • Ying Xue. et al. Application of TGF?1, TIMP?1 and TIMP?2 small interfering RNAs can alleviate CCl<sub>4</sub>?induced hepatic fibrosis in rats by rebalancing Th1/Th2 cytokines. Exp Ther Med. 2021 Sep;22(3):1-7Read more>>
  • Fangyu Qiao. et al. 4-Octyl itaconate modified demineralized bone matrix scaffold improves bone repair by regulating early inflammation. Chem Eng J. 2021 Dec;425:13149Read more>>
  • Dongdong Yao. et al. Matrix stiffness regulates bone repair by modulating 12-lipoxygenase-mediated early inflammation. Mat Sci Eng C-Mater. 2021 Sep;128:112359Read more>>
  • Si-Cheng Zhao. et al. Nickel sulfate exposure induces ovarian inflammation and fibrosis and decreases oocyte quality in mice. Ecotox Environ Safe. 2021 Nov;224:112634Read more>>
  • Liang, Wei. et al. Polarized M2 macrophages induced by mechanical stretching modulate bone regeneration of the craniofacial suture for midfacial hypoplasia treatment. 2021 Sep 27Read more>>
  • An Wang. et al. Yiqi Jiedu herbal decoction attenuates the 2?Gy 60Co ray induced spleen injury by inhibiting apoptosis and modulating the immune balance. J Ethnopharmacol. 2022 Mar;286:114925Read more>>
  • Meng-Meng ZHANG. et al. Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway. Chin J Nat Medicines. 2021 Dec;19:912Read more>>
  • Shaofeng Wu. et al. The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-B signaling pathway in the brain of ducks. Ecotox Environ Safe. 2021 Dec;228:112965Read more>>
  • Jiuyan Zhang. et al. Lycopene Alleviates Chronic Stress-Induced Spleen Apoptosis and Immunosuppression via Inhibiting the Notch Signaling Pathway in Rats. J Agr Food Chem. 2022;XXXX(XXX):XXX-XXXRead more>>
  • Fang Wan. et al. Curcumin activates the Nrf2 Pathway to alleviate AFB1-induced immunosuppression in the spleen of ducklings. Toxicon. 2022 Apr;209:18Read more>>
  • Leyi Xue. et al. A Composite Hydrogel Containing Mesoporous Silica Nanoparticles Loaded With Artemisia argyi Extract for Improving Chronic Wound Healing. Front Bioeng Biotech. 2022; 10: 825339Read more>>
  • Maoyu Ye. et al. Long-Term Exposure to Sulfur Dioxide Before Sensitization Decreased the Production of Specific IgE in HDM-Sensitized Allergic Rhinitis Mice. J INFLAMM RES. 2022; 15: 2477249Read more>>
  • Dian-Dong Hou. et al. Therapeutic effects of myricetin on atopic dermatitis in vivo and in vitro. PHYTOMEDICINE. 2022 Jul;102:1542Read more>>
  • Xiaoyu Guo. et al. Effects of Boric Acid Gel on Vaginal Candida albicans Infections and the Local Immune System in Mice. FRONT IMMUNOL. 2022; 13: 950215Read more>>
  • Qihui Luo. et al. Ameliorating Effects of TRIM67 against Intestinal Inflammation and Barrier Dysfunction Induced by High Fat Diet in Obese Mice. INT J MOL SCI. 2022 Jan;23(14):765Read more>>
  • Xiaoran Wang. et al. Effects of Lactiplantibacillus plantarum 19-2 on immunomodulatory function and gut microbiota in mice. FRONT MICROBIOL. 2022; 13: 926756Read more>>
  • Yang Liu. et al. Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of the lung and intestine are related. FRONT PHARMACOL. 2022 Sep 7;13:927384Read more>>
  • Xiaonan Li. et al. Facile One-Pot Synthesis of Meteor Hammer-like Au-MnOx Nanozymes with Spiky Surface for NIR-II Light-Enhanced Bacterial Elimination. CHEM MATER. 2022;XXXX(XXX):XXX-XXXRead more>>
  • Mingwei Tong. et al. The Trichinella spiralis-derived antigens alleviate HFD-induced obesity and inflammation in mice. INT IMMUNOPHARMACOL. 2023 Apr;117:109924Read more>>
  • Fangyu Qiao. et al. Hybrid Cell Membrane-Functionalized Matrixes for Modulating Inflammatory Microenvironment and Improving Bone Defect Repair. ADV HEALTHC MATER. 2023 Apr;:2203047Read more>>
  • Yang LIU. et al. Platycodon grandiflorus polysaccharide regulates colonic immunity through mesenteric lymphatic circulation to attenuate ulcerative colitis. CHIN J NAT MEDICINES. 2023 Apr;21:263Read more>>
  • Wen Changlin. et al. Dietary Zinc Ameliorates TNBS-Induced Colitis in Mice Associated with Regulation of Th1/Th2/Th17 Balance and NF-B/NLRP3 Signaling Pathway. BIOL TRACE ELEM RES. 2023 May;:1-12Read more>>
  • Xiangli Zhang. et al. Self-powered enzyme-linked microneedle patch for scar-prevention healing of diabetic wounds. SCI ADV. 2023 Jul;9(28)Read more>>
  • Sikai Wang. et al. Small Extracellular Vesicles Derived from Altered Peptide Ligand-Loaded Dendritic Cell Act as A Therapeutic Vaccine for Spinal Cord Injury Through Eliciting CD4+ T cell-Mediated Neuroprotective Immunity. Advanced Science. 2023 Nov;:2304648Read more>>
  • Yun Sun. et al. Inhibitory effects of catalpol on DNCB-induced atopic dermatitis and IgE-mediated mast cells reaction. INT IMMUNOPHARMACOL. 2024 Jan;126:111274Read more>>
  • Xianmou Fan. et al. A Multifunctional, Tough, Stretchable, and Transparent Curcumin Hydrogel with Potent Antimicrobial, Antioxidative, Anti-inflammatory, and Angiogenesis Capabilities for Diabetic Wound Healing. ACS APPL MATER INTER. 2024;16(8):9749C9767Read more>>
  • Kun Yang. et al. Melatonin restores DNFB-induced dysbiosis of skin microbiota in a mouse model of atopic dermatitis. LIFE SCI. 2024 Apr;342:122513Read more>>
  • Tian Meihui. et al. Mechanistic study of acupuncture on the pterygopalatine ganglion to improve allergic rhinitis: analysis of multi-target effects based on bioinformatics/network topology strategie. BRIEF BIOINFORM. 2024 Jun;25(4)Read more>>
  • Chuanqiang Wu. et al. Hypoxia inhibits the iMo/cDC2/CD8+ TRMs immune axis in the tumor microenvironment of human esophageal cancer. J IMMUNOTHER CANCER. 2024 Jul;12(7):e008889Read more>>
  • Zhenying Yuan. et al. Arecoline promotes fibroblast activation and M2-macrophage polarization by up-regulating the expression of IL-4. ARCH ORAL BIOL. 2024 Nov;167:106052Read more>>