bs-0610R-A350 [Conjugated Primary Antibody]
Adiponectin Receptor 1 Antibody, ALEXA FLUOR® 350 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Adiponectin Receptor 1

Immunogen Range: 241-270/375


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 51094

Swiss Prot: Q96A54

Source: KLH conjugated synthetic peptide derived from human Adiponectin Receptor 1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.

Conjugation: ALEXA FLUOR® 350

Excitation/ Emission: 346nm/442nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 42


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Liu, Su, et al. "The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats." European journal of pharmacology 650.1 (2011): 384.Read more>>
  • Ji, Hongfei, et al. "The effect of resveratrol on the expression of AdipoR1 in kidneys of diabetic nephropathy." Molecular Biology Reports: 1-9.Read more>>
  • Guo, Zhixin, et al. "Effect of exenatide on the cardiac expression of adiponectin receptor 1 and NADPH oxidase subunits and heart function in streptozotocin-induced diabetic rats." Diabetology & Metabolic Syndrome 6.1 (2014): 29.Read more>>
  • Morad, Vivian, Annelie Abrahamsson, and Charlotta Dabrosin. "Estradiol affects extracellular leptin: adiponectin ratio in human breast tissue in vivo." The Journal of Clinical Endocrinology & Metabolism (2014).Read more>>
  • Wang, Yajing, et al. "GRK2-Mediated Desensitization of AdipoR1 in Failing Heart." Circulation (2015): CIRCULATIONAHA-114.Read more>>
  • Wu, Ming-Hsiu, et al. "Obesity Exacerbates Rat Cerebral Ischemic Injury through Enhancing Ischemic Adiponectin-Containing Neuronal Apoptosis."Molecular Neurobiology (2015): 1-12.Read more>>
  • Cao, Zhongzan, et al. "Molecular cloning and expression analysis of adiponectin and its receptors (AdipoR1 and AdipoR2) in the hypothalamus of the Huoyan goose during different stages of the egg-laying cycle."Reproductive Biology and Endocrinology 13.1 (2015): 87.Read more>>
  • Liu, Gai-Zhen, et al. "High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation." Free Radical Biology and Medicine (2015).Read more>>
  • Li, Jiehua, Shiyue Su, and Xiaona Zong. "Analysis of the association between adiponectin, adiponectin receptor 1 and diabetic cardiomyopathy."Experimental and therapeutic medicine 7.4 (2014): 1023-1027.Read more>>
  • Guo et al. Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats. (2012) Cardiovasc.Diabetol. 11:94Read more>>
  • Jia Gao. et al. Nicotine aggravates vascular adiponectin resistance via ubiquitin-mediated adiponectin receptor degradation in diabetic Apolipoprotein E knockout mouse. Cell Death Dis. 2021 May;12(6):1-12Read more>>
  • Ruiying Liu. et al. Adiponectin inhibits D?gal?induced cardiomyocyte senescence via AdipoR1/APPL1. Mol Med Rep. 2021 Oct;24(4):1-1Read more>>
  • Annamria Schaffer. et al. The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility. Life Sci. 2022 May;297:120465Read more>>
  • Guoying Zhu. et al. Celecoxib-mediated attenuation of non-alcoholic steatohepatitis is potentially relevant to redistributing the expression of adiponectin receptors in rats. HELIYON. 2022 Jul;8:e09872Read more>>
VALIDATION IMAGES