bs-0638R-Cy5 [Conjugated Primary Antibody]
TGF Beta R1 Polyclonal Antibody, Cyanine 5 Conjugated
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]

Host: Rabbit

Target Protein: TGF beta Receptor 1

Immunogen Range: 301-400/501

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 7046

Swiss Prot: P36897

Source: KLH conjugated synthetic peptide derived from human TGF-beta R1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C; for long storage, store at -80°C. Avoid multiple freeze-thaw cycles


Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

Conjugation: Cyanine 5

Excitation/ Emission: 625,650nm/670nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)

Predicted Molecular Weight: 55

Cross Reactive Species: Human

Predicted Cross Reactive Species: Cow

For research use only. Not intended for diagnostic or therapeutic use.

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  • Yang, Xiao, et al. "Effect of Iodine Excess on Th1, Th2, Th17, and Treg Cell Subpopulations in the Thyroid of NOD. H-2h4 Mice." Biological Trace Element Research (2014): 1-9.Read more>>
  • Tang, K., et al. "GDF9 affects the development and tight junction functions of immature bovine Sertoli cells." Reproduction in Domestic Animals (2017).Read more>>
  • Cashman et al. SENP5 mediates breast cancer invasion via a TGFβRI SUMOylation cascade. (2014) Oncotarge. 5:1071-82Read more>>
  • Li et al. TNF-α enhances the effect of TGF-β on Gli2 expression in the KG-1 leukemic cell line. (2014) Exp.Ther.Me. 8:676-680Read more>>
  • Yan Zheng. et al. Downregulation of Rap1GAP Expression Activates the TGF-/Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells. Biomed Res Int. 2021;2021:6840642Read more>>