bs-0654R-Biotin [Conjugated Primary Antibody]
GHR Polyclonal Antibody, Biotin Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: GHR

Immunogen Range: 101-200/451


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2690

Swiss Prot: P10912

Source: KLH conjugated synthetic peptide derived from human GHR

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)

Predicted Molecular Weight: 68


Cross Reactive Species: Human
Mouse
Rat
Pig
Sheep
Others

Predicted Cross Reactive Species: Dog
Cow
Chicken

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yang, Hai Li, et al. "Effect of suppressor of cytokine signaling 2 (SOCS2) on fat metabolism induced by growth hormone (GH) in porcine primary adipocyte." Molecular biology reports 39.9 (2012): 9113-9122.Read more>>
  • Wang, Zheng, et al. "RhGH attenuates ischemia injury of intrahepatic bile ducts relating to liver transplantation." Journal of Surgical Research 171.1 (2011): 300-310.Read more>>
  • Hetz, Jennifer A., et al. "Growth axis maturation is linked to nutrition, growth and developmental rate." Molecular and Cellular Endocrinology (2015).Read more>>
  • Song, Cheng-Jun, et al. "Effects of sericin on the testicular growth hormone/insulin-like growth factor-1 axis in a rat model of type 2 diabetes." International Journal of Clinical and Experimental Medicine 8.7 (2015): 10411-10419.Read more>>
  • Zhao, Yong, et al. "Inhibition of peripubertal sheep mammary gland development by cysteamine through reducing progesterone and growth factor production." Theriogenology (2016).Read more>>
  • Chu, Meiqiang, et al. "MicroRNA-126 participates in lipid metabolism in mammary epithelial cells." Molecular and Cellular Endocrinology (2017).Read more>>
  • Zhou et al. Effects of zearalenone on the localization and expression of the growth hormone receptor gene in the uteri of post-weaning piglets. (2018) Asian-Australas.J.Anim.Sci. 31:32-39Read more>>
  • Chen et al. Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis. (2013) Neural.Regen.Res. 8:1756-64Read more>>
  • Cui et al. Generation of a miniature pig disease model for human Laron syndrome. (2015) Sci.Rep. 5:15603Read more>>
  • Xie W et al. Seasonal expressions of growth hormone receptor, insulin-like growth factor 1 and insulin-likegrowth factor 1 receptor in the scented glands of the muskrats (Ondatra zibethicus). Gen Comp Endocrinol. 2019 May 20;281:58-66. Read more>>
  • Zhou M et al. Comparative study of stress response, growth and development of uteri in post‐weaning gilts challenged with zearalenone and estradiol benzoate. J Anim Physiol Anim Nutr (Berl). 2019 Sep 4. Read more>>
  • Fengyang Wu. et al. Effects of zearalenone on ovarian development of prepubertal gilts through growth hormone axis. FRONT VET SCI. 2022; 9: 950063Read more>>
  • Ahmed O. Kaseb. et al. Blockade of growth hormone receptor signaling by using pegvisomant: A functional therapeutic strategy in hepatocellular carcinoma.. FRONT ONCOL. 2022 Oct;12:986305-986305Read more>>
  • Hu Bowen. et al. Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation. CELL COMMUN SIGNAL. 2023 Dec;21(1):1-18Read more>>
VALIDATION IMAGES