bs-0665R-A350 [Conjugated Primary Antibody]
PIWIL1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated
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Host: Rabbit

Target Protein: PIWIL1

Immunogen Range: 551-650/861


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 416804

Swiss Prot: A6N7Y9

Source: KLH conjugated synthetic peptide derived from chicken PIWIL1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 3 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).

Conjugation: ALEXA FLUOR® 350

Excitation/ Emission: 346nm/442nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 95


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat
Chicken

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Liu, Wen-Kang, Xiang-Yang Jiang, and Zhen-Xi Zhang. "Expression of PSCA, PIWIL1 and TBX2 and its correlation with HPV16 infection in formalin-fixed, paraffin-embedded cervical squamous cell carcinoma specimens." Archives of virology 155.5 (2010): 657-663.Read more>>