bs-0668R-BF647 [Conjugated Primary Antibody]
MET Polyclonal Antibody, AbBy Fluor-647 Conjugated
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Host: Rabbit

Target Protein: MET

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4233

Swiss Prot: P16056

Source: KLH conjugated synthetic peptide derived from mouse MET

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

Conjugation: AbBy Fluor-647

Excitation/ Emission: 650nm/665nm

Size: 100µL

Concentration: 1mg/ml

Applications: WB(1:500-2000)
IF(1:100-500)

Predicted Molecular Weight: 33/123/156


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Gao, Wei, et al. "Study of critical role of c-Met and its inhibitor SU11274 in colorectal carcinoma." Medical Oncology 30.2 (2013): 1-8.Read more>>
  • Yu, Xiuju, et al. "Expression and tissue distribution of hepatocyte growth factor (HGF) and its receptor (c-Met) in alpacas (Vicugna pacos) skins associated with white and brown coat colors." Acta Histochemica (2015).Read more>>
  • Li, Hongyu, et al. "Overexpression of MACC1 and the association with hepatocyte growth factor/c-Met in epithelial ovarian cancer." Oncology letters9.5 (2015): 1989-1996.Read more>>
  • Wang, Xinhong, et al. "Hepatocyte growth factor (HGF) optimizes oral traumatic ulcer healing of mice by reducing inflammation." Cytokine (2017).Read more>>
  • Qi et al. Therapeutic role of human hepatocyte growth factor (HGF) in treating hair loss. (2016) Peer. 4:e2624Read more>>
  • Guo et al. Expression of MACC1 and c-Met in human gastric cancer and its clinical significance. (2013) Cancer.Cell.Int. 13:121Read more>>
  • Shi Yan. et al. The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC. Anal Cell Pathol. 2022;2022:9651503Read more>>
  • Tang-Yuan Chu. et al. Effect of ovulation IGF and HGF signaling on the oncogenesis of murine epithelial ovarian cancer cell ID8. EXP CELL RES. 2022 Oct;419:113323Read more>>
  • Tang-Yuan Chu. et al. Insulin-like growth factor (IGF) and hepatocyte growth factor (HGF) in follicular fluid cooperatively promote the oncogenesis of high-grade serous carcinoma from fallopian tube epithelial cells: Dissection of the molecular effects. MOL CARCINOGEN. 2023 JuRead more>>
  • Yang Zilin. et al. MicroRNA-130b Suppresses Malignant Behaviours and Inhibits the Activation of the PI3K/Akt Signaling Pathway by Targeting MET in Pancreatic Cancer. BIOCHEM GENET. 2024 Apr;:1-26Read more>>