bs-0741R-Cy7 [Conjugated Primary Antibody]
CDKN1A Polyclonal Antibody, Cy7 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CDKN1A

Immunogen Range: 101-164/164


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 12575

Swiss Prot: P38936

Source: KLH conjugated synthetic peptide derived from human CDKN1A

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).

Conjugation: Cy7

Excitation/ Emission: 743nm/767nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 18


Cross Reactive Species: Human
Mouse
Rat
Sheep

Predicted Cross Reactive Species: Dog
Cow
Chicken

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Chen, Jie, et al. "Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis." BMC cancer 12.1 (2012): 464.Read more>>
  • Li, Lv, et al. "Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition." Cancer cell international 12.1 (2012): 1-6.Read more>>
  • Jindou Jiang, Yong Miao, et al. "DAPT in the control of human hair follicle stem cell proliferation and differentiation." Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii 31.4 (2014): 201.Read more>>
  • Yang et al. RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells. (2011) J.Biol.Che. 286:11865-74Read more>>
  • Yang et al. RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells. (2011) J.Biol.Che. 286:11865-74Read more>>
  • Shen S et al. Transcription factor early growth response-1 plays an oncogenic role in salivary gland pleomorphic adenoma. Biotechnol Lett. 2019 Nov 30.Read more>>
  • Niu K et al. Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation. PLoS One. 2020 Jan 15;15(1):e0227408.Read more>>
  • Shi L et al. Effects of selenium on the proliferation and apoptosis of sheep spermatogonial stem cells in vitro. Animal Reproduction Science, 2020, 106330. Read more>>
  • Gong Y et al. Smad3 C-terminal phosphorylation site mutation attenuates the hepatoprotective effect of salvianolic acid B against hepatocarcinogenesisFood Chem Toxicol.2021 Jan;147:111912.Read more>>
  • Yunping Lu. et al. Peroxiredoxin1 Knockdown Inhibits Oral Carcinogenesis via Inducing Cell Senescence Dependent on Mitophagy. Oncotargets Ther. 2021; 14: 239C251Read more>>
  • Feng Cui. et al. ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1–BLM Interaction. CELLS-BASEL. 2023 Jan;12(1):145Read more>>
  • Yue Zhang. et al. Dietary selenium excess affected spermatogenesis via DNA damage and telomere-related cell senescence and apoptosis in mice. FOOD CHEM TOXICOL. 2023 Jan;171:113556Read more>>
  • Keiichi Hiramoto. et al. Bacillus coagulans (species of lactic acid-forming Bacillus bacteria) ameliorates azoxymethane and dextran sodium sulfate-induced colon cancer in mice. J FUNCT FOODS. 2023 Jan;100:105406Read more>>
  • Fang Wu. et al. Ribosomal protein L31 (RPL31) inhibits the proliferation and migration of gastric cancer cells. HELIYON. 2023 Jan;:e13076Read more>>
  • Jinxin Ma. et al. Bioinformatics and Integrative Experimental Method to Identifying and Validating Co-Expressed Ferroptosis-Related Genes in OA Articular Cartilage and Synovium. J INFLAMM RES. 2024 Feb 11Read more>>
VALIDATION IMAGES