bs-0877R-BF350 [Conjugated Primary Antibody]
beta-Amyloid 1-40 Polyclonal Antibody, AbBy Fluor® 350 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: beta-Amyloid 1-40 CT

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 351

Source: KLH conjugated synthetic peptide derived from human beta-Amyloid 1-40

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid and peptides have been developed as tools for elucidating the biology of Alzheimer's disease.

Conjugation: AbBy Fluor® 350

Excitation/ Emission: 346nm/442nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)

Cross Reactive Species: Human
Mouse
Rat
Bovine
Dog
Pig
Chicken

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Fang, Fang, et al. "Alzheimer’s disease Animal Model by Aluminum, Beta-Amyloid and Transforming Growth Factor Beta-1." Aging and Neurodegeneration, Vol. 1 (1): 15-19Read more>>
  • An et al. Pharmacological Basis for Use ofArmillaria melleaPolysaccharides in Alzheimer's Disease: Antiapoptosis and Antioxidation. (2017) Oxid.Med.Cell.Longev. 2017:4184562Read more>>
  • Hu et al. Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis. (2018) Mol.Med.Rep.Nov;18(5):4289-4296. Read more>>
  • Yu H et al. Protective roles of isoastilbin against Alzheimer's disease via Nrf2‑mediated antioxidation and anti‑apoptosis. Int J Mol Med. 2019 Mar;43(3):1406-1416.Read more>>
  • Yu-Shi Gong. et al. Effects of alcohol intake on cognitive function and -amyloid protein in APP/PS1 transgenic mice. Food Chem Toxicol. 2021 May;151:112105Read more>>
  • Hong Zhao. et al. Polysaccharides from sea buckthorn (Hippophae rhamnoides L.) berries ameliorates cognitive dysfunction in AD mice induced by a combination of D-gal and AlCl3 by suppressing oxidative stress and inflammation reaction. J SCI FOOD AGR. 2023 MayRead more>>