bs-0988R-PE [Conjugated Primary Antibody]
Transferrin receptor Polyclonal Antibody, PE Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Transferrin receptor

Immunogen Range: 621-720/760


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 7037

Swiss Prot: P02786

Source: KLH conjugated synthetic peptide derived from human Transferrin receptor

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Conjugation: PE

Excitation/ Emission: 496,564nm/578nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)

Predicted Molecular Weight: 74/85


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat
Dog
Cow
Pig
Horse
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Song Q et al. Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-B activationToxicol Appl Pharmacol.2021 Jan 1;410:115361.Read more>>
  • Mingang Hao. et al. Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release Via Small Extracellular Vesicles. Dev Cell. 2021 Feb;56:341Read more>>
  • Sarah Almas. et al. Cytokine trafficking of IL\9 and IL\13 through TfnRc+ vesicles in activated human eosinophils. 2020 Sep 1Read more>>
  • Das Oishika. et al. Butyrate driven raft disruption trots off enteric pathogen invasion: possible mechanism of colonization resistance. GUT PATHOG. 2023 Dec;15(1):1-14Read more>>
  • Limin Shi. et al. FoxO1 regulates adipose transdifferentiation and iron influx by mediating Tgf1 signaling pathway. REDOX BIOL. 2023 Jul;63:102727Read more>>
  • Yu-Sheng Shi. et al. Dendrobine rescues cognitive dysfunction in diabetic encephalopathy by inhibiting ferroptosis via activating Nrf2/GPX4 axis. PHYTOMEDICINE. 2023 Jul;:154993Read more>>
  • Huan Yang. et al. Heat stress induces ferroptosis of porcine Sertoli cells by enhancing CYP2C9-Ras- JNK axis. THERIOGENOLOGY. 2024 Feb;215:281Read more>>
VALIDATION IMAGES