bs-10008R-BF555 [Conjugated Primary Antibody]
Claudin 1 Polyclonal Antibody, AbBy Fluor-555 Conjugated
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Host: Rabbit

Target Protein: Claudin 1

Immunogen Range: 30-80/211


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 9076

Source: KLH conjugated synthetic peptide derived from human Claudin 1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq].

Conjugation: AbBy Fluor-555

Excitation/ Emission: 553nm/568nm

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Xiaoli Gao. et al. Effects of Clostridium perfringens beta2 toxin on apoptosis, inflammation, and barrier function of intestinal porcine epithelial cells. Microb Pathogenesis. 2020 Oct;147:104379Read more>>
  • Wenjuan Xun. et al. Resveratrol protects intestinal integrity, alleviates intestinal inflammation and oxidative stress by modulating AhR/Nrf2 pathways in weaned piglets challenged with diquat. Int Immunopharmacol. 2021 Oct;99:107989Read more>>
  • Qing Li. et al. Fumonisin B1 Inhibits Cell Proliferation and Decreases Barrier Function of Swine Umbilical Vein Endothelial Cells. Toxins. 2021 Dec;13(12):863Read more>>
  • D.L. Wu. et al. Dietary supplementation of free or two fat-coated sodium butyrate with varying release times on gastrointestinal development and tight junctions in preweaning Holstein calves. Anim Feed Sci Tech. 2022 Mar;285:115224Read more>>
  • Kexin Wang. et al. Phloretin Protects Bovine Rumen Epithelial Cells from LPS-Induced Injury. TOXINS. 2022 May;14(5):337Read more>>
  • Jian Kang. et al. Ginsenoside Rg1 Mitigates Porcine Intestinal Tight Junction Disruptions Induced by LPS through the p38 MAPK/NLRP3 Inflammasome Pathway. TOXICS. 2022 Jun;10(6):285Read more>>
  • Guangdong Bai. et al. Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function. ENVIRON INT. 2022 Dec;170:107579Read more>>
  • Guangdong Bai. et al. Perinatal exposure to high concentration glyphosate-based herbicides induces intestinal apoptosis by activating endoplasmic reticulum stress in offspring. SCI TOTAL ENVIRON. 2023 Mar;865:161223Read more>>
  • Wenjuan Xun. et al. Dietary emodin alleviates lipopolysaccharide-induced intestinal mucosal barrier injury by regulating gut microbiota in piglets. ANIM NUTR. 2023 MayRead more>>
  • Wang Lei. et al. Soybean glycinin and -conglycinin damage the intestinal barrier by triggering oxidative stress and inflammatory response in weaned piglets. EUR J NUTR. 2023 Jun;:1-14Read more>>
  • Leihong Cui. et al. Lactiplantibacillus plantarum L47 and inulin alleviate enterotoxigenic Escherichia coli induced ileal inflammation in piglets by upregulating the levels of -linolenic acid and 12,13-epoxyoctadecenoic acid. ANIM NUTR. 2023 JulRead more>>
  • Dong-dong Zhao. et al. Dietary taurine effect on intestinal barrier function, colonic microbiota and metabolites in weanling piglets induced by LPS. FRONT MICROBIOL. 2023; 14: 1259133Read more>>
  • Qingya Liu. et al. Camptothecin multifunctional nanoparticles effectively achieve a balance between the efficacy of breast cancer treatment and the preservation of intestinal homeostasis. BIOACT MATER. 2024 Nov;41:413Read more>>
  • Xiaobin Wen. et al. The PI3K/Akt-Nrf2 Signaling Pathway and Mitophagy Synergistically Mediate Hydroxytyrosol to Alleviate Intestinal Oxidative Damage. INT J BIOL SCI. 2024; 20(11): 42584276Read more>>
  • Wen Xiaobin. et al. Caffeic acid modulates intestinal microbiota, alleviates inflammatory response, and enhances barrier function in a piglet model challenged with lipopolysaccharide. J ANIM SCI. 2024 AugRead more>>