Target Protein: gp130 Ser782
Modification Site: Ser782
Entrez Gene: 3572
Swiss Prot: P40189
Source: KLH conjugated synthetic phosphopeptide derived from human gp130 around the phosphorylation site of Ser782
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage: Store at -20°C for 12 months.
Background: CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Cross Reactive Species:
Predicted Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.