bs-10123R-Cy5 [Conjugated Primary Antibody]
IKK alpha / beta Polyclonal Antibody, Cyanine 5 Conjugated
www.biossusa.com
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DATASHEET

Host: Rabbit

Target Protein: IKK alpha / beta

Immunogen Range: 151-250/756


Clonality: Polyclonal

Isotype: IgG

Source: KLH conjugated synthetic peptide derived from human IKK Alpha/IKK beta

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C; for long storage, store at -80°C. Avoid multiple freeze-thaw cycles

Background:

IKK Alpha/IKK beta is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.

Conjugation: Cyanine 5

Excitation/ Emission: 625,650nm/670nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 83


Cross Reactive Species: Mouse

Predicted Cross Reactive Species: Human
Rat
Dog
Cow
Pig
Horse
Chicken

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Qihong Zhang. et al. ACSL1 Inhibits ALV-J Replication by IFN- Signaling and PI3K/Akt Pathway. Front Immunol. 2021; 12: 774323Read more>>
  • Yuhua Li. et al. Study on the mechanism of Yupingfeng powder in the treatment of immunosuppression based on UPLC?QTOF?MS, network pharmacology and molecular biology verification. Life Sci. 2022 Jan;289:120211Read more>>