Target Protein: LAT Tyr161
Modification Site: Tyr161
Entrez Gene: 27040
Swiss Prot: O43561
Source: KLH conjugated synthetic phosphopeptide derived from human LAT around the phosphorylation site of Tyr161
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage: Store at -20°C for 12 months.
Background: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Predicted Molecular Weight: 29
Predicted Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.