bs-1012R-A594 [Conjugated Primary Antibody]
BMP2 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: BMP2

Immunogen Range: 283-365/396


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 650

Swiss Prot: P12643

Source: KLH conjugated synthetic peptide derived from human BMP2

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily of secreted growth factors. It is a disulfide-linked homodimer and induces bone and cartilage formation. In addition to its osteogenic activity, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. BMPs control fundamental events in early embryonic development, organogenesis and adult tissue homeostasis.

Conjugation: ALEXA FLUOR® 594

Excitation/ Emission: 590nm/617nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 44


Cross Reactive Species: Human
Mouse
Rat
Sheep
Rabbit

Predicted Cross Reactive Species: Dog
Cow
Horse
Chicken

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Wei B et al. Osteoprotegerin/bone morphogenetic protein 2 combining with collagen sponges on tendon-bone healing in rabbits. J Bone Miner Metab. 2020 Jan 24. Read more>>
  • Huang, Guo-fu, et al. "The Effect of Electroacupuncture on the Extracellular Matrix Synthesis and Degradation in a Rabbit Model of Disc Degeneration." Evidence-Based Complementary and Alternative Medicine 2014 (2014).Read more>>
  • Yasuda, Hiromitsu, et al. "Osteogenic Effect of Local Administration of Fluvastatin using a Fluvastatin-gelatin Complex in Senile Osteoporosis Model Rat." Journal of Hard Tissue Biology 23.4 (2014): 389-398.Read more>>
  • Zhu, Wenjing, et al. "Effect of PI3K/Akt Signaling Pathway on the Process of Prostate Cancer Metastasis to Bone." Cell Biochemistry and Biophysics (2015): 1-7.Read more>>
  • Naeem, A. S., et al. "AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation." Cell Death & Differentiation (2015).Read more>>
  • Kishi, Yuta, et al. "PARP Inhibitor PJ34 Suppresses Osteogenic Differentiation in Mouse Mesenchymal Stem Cells by Modulating BMP-2 Signaling Pathway."International Journal of Molecular Sciences 16.10 (2015): 24820-24838.Read more>>
  • Zhang, Jing, et al. "Combination of simvastatin, calcium silicate/gypsum, and gelatin and bone regeneration in rabbit calvarial defects." Scientific Reports 6 (2016): 23422.Read more>>
  • Zhou, Zhixuan, et al. "CBX7 deficiency plays a positive role in dentin and alveolar bone development." Journal of Molecular Histology: 1-11.Read more>>
  • Wu, Guoping, et al. "Gene Expression of Osteogenic Factors Following Gene Therapy in Mandibular Lengthening." Journal of Craniofacial Surgery26.2 (2015): 378-381.Read more>>
  • Sari, Agnes Rosarina Prita, et al. "Characterization of ovine dermal papilla cell aggregation." International Journal of Trichology 8.3 (2016): 121.Read more>>
  • Wu et al. Expression analysis of BMP2, BMP5, BMP10 in human colon tissues from Hirschsprung disease patients. (2014) Int.J.Clin.Exp.Patho. 7:529-36Read more>>
  • Wu et al. Expression analysis of BMP2, BMP5, BMP10 in human colon tissues from Hirschsprung disease patients. (2014) Int.J.Clin.Exp.Patho. 7:529-36Read more>>
  • Xiong et al. BMP2-loaded hollow hydroxyapatite microspheres exhibit enhanced osteoinduction and osteogenicity in large bone defects. (2015) Int.J.Nanomedicin. 10:517-26Read more>>
  • Wu et al. Negative Pressure Therapy in the Regeneration of the Sciatic Nerve Using Vacuum - Assisted Closure in a Rabbit Model. (2018) Med.Sci.Monit. 24:1027-1033Read more>>
  • Wang et al. Effects of the antihypertensive drug benidipine on osteoblast function in vitro. (2014) Exp.Ther.Med. 7:649-653Read more>>
  • "Chen X et al. Modulation of proliferation and differentiation of gingiva‑derived mesenchymal stem cells by concentrated growth factors: Potential implications in tissue engineering for dental regeneration and repair. Send to Int J Mol Med. 2019 Apr 24. "Read more>>
  • Li Z et al. Angiogenesis and bone regeneration by allogeneic mesenchymal stem cell intravenous transplantation in rabbit model of avascular necrotic femoral head. J Surg Res. 2013 Jul;183(1):193-203. Read more>>
  • Diao S et al. IGF2 enhanced the osteo‐/dentinogenic and neurogenic differentiation potentials of stem cells from apical papilla. J Oral Rehabil. 2019 Jul 10. Read more>>
  • Li Y et al. Sulfonated chitosan oligosaccharide alleviates the inhibitory effect of basic fibroblast growth factor on osteogenic differentiation of human periodontal ligament stem cells. J Periodontol. 2019 Oct 1.Read more>>
  • Wei B et al. Osteoprotegerin/bone morphogenetic protein 2 combining with collagen sponges on tendon-bone healing in rabbits. J Bone Miner Metab. 2020 Jan 24. Read more>>
  • Jiarong Yanget al. Effects of Different Doses of Calcium on the Mitochondrial Apoptotic Pathway and Rho/ROCK Signaling Pathway in the Bone of Fluorosis Rats. Biol Trace Elem Res. 2020 Jul 25.Read more>>
  • Taiga Ono. et al. Generation of biohybrid implants using a multipotent human periodontal ligament cell line and bioactive core materials. 2021 Feb 19Read more>>
  • Li Zhilang. et al. Uterine Scarring Leads to Adverse Pregnant Consequences by Impairing the Endometrium Response to Steroids. Endocrinology. 2020 Nov;161(11)Read more>>
  • Shiyi Huang. et al. Transforming Growth Factor-3/Recombinant Human-like Collagen/Chitosan Freeze-Dried Sponge Primed With Human Periodontal Ligament Stem Cells Promotes Bone Regeneration in Calvarial Defect Rats. Front Pharmacol. 2021; 12: 678322Read more>>
  • Yu Guo. et al. RepSox effectively promotes the induced differentiation of sheep fibroblasts into adipocytes via the inhibition of the TGF?1/Smad pathway. Int J Mol Med. 2021 Aug;48(2):1-13Read more>>
  • Liu, Jie. et al. Phosphorylated PAMAM dendrimers: an analog of dentin non-collagenous proteins, enhancing the osteo/odontogenic differentiation of dental pulp stem cells. 2021 Sep 13Read more>>
  • Yifan Pan. et al. Disturbance in transcriptomic profile, proliferation and multipotency in human mesenchymal stem cells caused by hexafluoropropylene oxides. Environ Pollut. 2022 Jan;292:118483Read more>>
  • Ylmaz, Birtan Tolga. et al. In vivo efficacy of low-level laser therapy on bone regeneration. Laser Med Sci. 2022 Jan;:1-8Read more>>
  • L Cheng. et al. Toxic effects of thioacetamide-induced femoral damage in New Zealand white rabbits by activating the p38/ERK signaling pathway. PHYSIOL RES. 2022 Apr 11Read more>>
  • angbang Liang. et al. Proportion-dependent osteogenic activity of electrospun nano-hydroxyapatite/polylactic acid fiber membrane in vitro and in vivo. MATER DESIGN. 2022 Jul;219:110834Read more>>
  • Yu Hedong. et al. Improved repair of rabbit calvarial defects with hydroxyapatite/chitosan/polycaprolactone composite scaffold-engrafted EPCs and BMSCs. FRONT BIOENG BIOTECH. 2022 Aug;0:1275Read more>>
  • Song, Yanqiu. et al. Iron overload impairs renal function and is associated with vascular calcification in rat aorta. BIOMETALS. 2022 Sep;:1-15Read more>>
  • Shimin Hao. et al. Evaluation of Biodegradable Alloy Fe30Mn0.6N in Rabbit Femur and Cartilage through Detecting Osteogenesis and Autophagy. BIOMED RES INT. 2023 Jan 18;2023:3626776Read more>>
  • Kai Wang. et al. Network Pharmacological Analysis and Animal Experimental Study on Osteoporosis Treatment with GuBen-ZengGu Granules. EVID-BASED COMPL ALT. 2023 Jan 12;2023:9317557Read more>>
  • Haojun Liang. et al. A Bone-Penetrating Precise Controllable Drug Release System Enables Localized Treatment of Osteoporotic Fracture Prevention via Modulating Osteoblast-Osteoclast Communication. SMALL. 2023 Mar;:2207195Read more>>
  • Chengzhong Xu. et al. Microenvironment responsive hypoxia-mimetic DFO composite hydrogel for on-demand neovascularization to promote tendon-to-bone healing. COMPOS PART B-ENG. 2023 Apr;:110726Read more>>
  • Yuanchao Zhu. et al. Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/-Catenin Signaling Pathway. ACS BIOMATER-SCI ENG. 2023;XXXX(XXX):XXX-XXXRead more>>
  • Changjun Chen. et al. Engineered Exosome-Functionalized Extracellular Matrix-Mimicking Hydrogel for Promoting Bone Repair in Glucocorticoid-Induced Osteonecrosis of the Femoral Head. ACS APPL MATER INTER. 2023;XXXX(XXX):XXX-XXXRead more>>
VALIDATION IMAGES