bs-10200R-PE [Conjugated Primary Antibody]
Sclerostin Polyclonal Antibody, PE Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Sclerostin

Immunogen Range: 121-180/213


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 50964

Swiss Prot: Q9BQB4

Source: KLH conjugated synthetic peptide derived from human Sclerostin

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

Conjugation: PE

Excitation/ Emission: 496,564nm/578nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)

Predicted Molecular Weight: 21


Cross Reactive Species: Human
Mouse
Rat
Rabbit

Predicted Cross Reactive Species: Dog
Cow
Sheep
Pig
Horse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Diao et al. The Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact. (2017) Sci.Rep. 7:6508Read more>>
  • Surowiec RK et al. A Xenograft Model to Evaluate the Bone Forming Effects of Sclerostin Antibody in Human Bone Derived from Pediatric Osteogenesis Imperfecta Patients. Bone. 2020 Jan;130:115118.Read more>>
  • Zhang C et al. FOXO1 Mediates Advanced Glycation End Products Induced Mouse Osteocyte-Like MLO-Y4 Cell Apoptosis and Dysfunctions. Journal of Diabetes Research.2019, Article ID 6757428.Read more>>
  • Yiqi Yanget al. Bioprinting of an osteocyte network for biomimetic mineralization. Biofabrication. 2020 Jul 29;12(4):045013.Read more>>
  • Yoo-Sung Nam. et al. Sclerostin in Periodontal Ligament: Homeostatic Regulator in Biophysical Force-Induced Tooth Movement. J CLIN PERIODONTOL. 2022 Apr 03Read more>>
  • Young Jae Moon. et al. Sirtuin 6 Overexpression Improves Rotator Cuff Tendon-to-Bone Healing in the Aged. CELLS-BASEL. 2023 Jan;12(16):2035Read more>>
  • Chen Shengqiang. et al. Local H2 release remodels senescence microenvironment for improved repair of injured bone. NAT COMMUN. 2023 Nov;14(1):1-16Read more>>