bs-10206R-A350

DATASHEET

Host: Rabbit

Target Protein: SP-A

Specificity: This antibody will detect both SFTPA1 and SFTPA2

Immunogen Range: 200-240/248

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 653509; 729238

Swiss Prot: Q8IWL2; Q8IWL1

Source: KLH conjugated synthetic peptide derived from human SFTPA1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Genes encoding pulmonary-surfactant associated proteins (SFTPA) are located on chromosome 10. Mutations in these genes, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. In presence of calcium ions, SFTPA1/SFTPA2 binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. These genes encode a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens.

Conjugation: ALEXA FLUOR® 350

Excitation/ Emission: 346nm/442nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.