bs-10234R [Primary Antibody]
CXCL1 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CXCL1

Immunogen Range: 51-107/107


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 14825

Swiss Prot: P12850

Source: KLH conjugated synthetic peptide derived from mouse CXCL1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity.

Size: 100ul

Concentration: 1ug/ul

Applications: ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
ICC(1:100-500)

Predicted Molecular Weight: 7.8


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Ito, Ryoji, et al. "A novel xenogeneic graft‐versus‐host disease model for investigating the pathological role of human CD4+ or CD8+ T cells using immunodeficient NOG mice." American Journal of Transplantation (2016).Read more>>
  • enedict D. Michael. et al. Astrocyte- and Neuron-Derived CXCL1 Drives Neutrophil Transmigration and Blood-Brain Barrier Permeability in Viral Encephalitis. Cell Rep. 2020 Sep;32:10815Read more>>
  • Rossella Di Sapia. et al. CXCL1-CXCR1/2 signaling is induced in human temporal lobe epilepsy and contributes to seizures in a murine model of acquired epilepsy. Neurobiol Dis. 2021 Oct;158:105468Read more>>
  • Odum James D.. et al. Candidate Biomarkers for Sepsis-Associated Acute Kidney Injury Mechanistic Studies. SHOCK. 2022 May;57(5):687-693Read more>>
  • Tianrui Zhang. et al. Daphnetin alleviates neuropathic pain in chronic constrictive injury rats via regulating the NF-B dependent CXCL1/CXCR2 signaling pathway. PHARM BIOL. 2023;61(1):746-754Read more>>
  • Dohi Akihiro. et al. Acute stress transiently activates macrophages and chemokines in cervical lymph nodes. IMMUNOL RES. 2024 Feb;:1-13Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded human spleen labeled with CXCL1 Polyclonal Antibody, Unconjugated (bs-10234R) at 1:400. Image courtesy of Yi Zhang at Cedars-Sinai Medical Center.