bs-1049R-Biotin [Conjugated Primary Antibody]
CHRNA7 Polyclonal Antibody, Biotin Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CHRNA7

Immunogen Range: 441-502/502


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1139

Swiss Prot: P36544

Source: KLH conjugated synthetic peptide derived from human CHRNA7

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)

Predicted Molecular Weight: 55


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Chicken

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Gao Y et al. Effect of splenectomy on attenuation of LPS-induced AKI through GTS-21-induced cholinergic anti-inflammatory pathway. Am J Transl Res. 2019 Apr 15;11(4):2540-2549. Read more>>
  • Sallam MY et al. Brainstem cholinergic pathways diminish cardiovascular and neuroinflammatory actions of endotoxemia in rats: Role of NFκB/α7/α4β2AChRs signaling. Neuropharmacology. 2019 Jun 25;157:107683. Read more>>
  • T.C. Peixoto. et al. Nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats. Appetite. 2021 May;160:105115Read more>>
  • Yang Gao. et al. Mechanisms of Renal-Splenic Axis Involvement in Acute Kidney Injury Mediated by the 7nAChR-NF-B Signaling Pathway. 2020 Nov 03Read more>>
  • Han Yang. et al. A Novel Targeted and High\Efficiency Nanosystem for Combinational Therapy for Alzheimer's Disease. Adv Sci. 2020 Oct;7(19):1902906Read more>>
  • Marta Pernarella. et al. Effects mediated by the 7 nicotinic acetylcholine receptor on cell proliferation and migration in rat adipose-derived stem cells. Eur J Histochem. 2020 Jun 19; 64(Suppl 2): 3159Read more>>
  • Mahmoud E. Youssef. et al. 7-nAChRs-mediated therapeutic angiogenesis accounts for the advantageous effect of low nicotine doses against myocardial infarction in rats. Eur J Pharmacol. 2021 Mar;:173996Read more>>
  • Martins I. C. A.. et al. Omega-3 Supplementation Prevents Short-Term High-Fat Diet Effects on the 7 Nicotinic Cholinergic Receptor Expression and Inflammatory Response. Mediat Inflamm. 2021;2021:552694Read more>>
  • H.E. Burzynski. et al. Pyridostigmine bromide elicits progressive and chronic impairments in the cholinergic anti-inflammatory pathway in the prefrontal cortex and hippocampus of male rats. NEUROBIOL STRESS. 2022 May;18:100446Read more>>
  • Suleyma Oliveira Costa. et al. Maternal consumption of a high-fat diet modulates the inflammatory response in their offspring, mediated by the M1 muscarinic receptor. FRONT IMMUNOL. 2023; 14: 1273556Read more>>
  • He Ying. et al. Elucidating the mechanisms of formononetin in modulating atherosclerotic plaque formation in ApoE-/- mice. BMC CARDIOVASC DISOR. 2024 Dec;24(1):1-11Read more>>
VALIDATION IMAGES