bs-106351P

DATASHEET

Swiss Prot: P21237

Source: Recombinant Mouse BDNF Protein is expressed in E.coli with N-His. It contains the amino acid sequence of 130-249/249

Storage Buffer: Lyophilized from a solution in 10mM PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Storage: The product should be stored at -70°C or -20°C.

Background:

Neurotrophins function to regulate naturally occurring cell death of neurons during development. The prototype neurotrophin is nerve growth factor (NGF), originally discovered in the 1950s as a soluble peptide promoting the survival of, and neurite outgrowth from, sympathetic ganglia. More recently, three additional structurally homologous neurotrophic factors have been identified. These include brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4), also designated NT-5. These various neurotrophins stimulate the in vitro survival of distinct but partially overlapping populations of neurons. The Trk A receptor is the preferential receptor for NGF, but also binds NT-3 and NT-4. The Trk B receptor binds equally well to both BDNF and NT-4 and to a lesser extent NT-3, while the Trk C receptor only binds NT-3. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Belongs to the NGF-beta family.

Sequence: 130-249/249

Size: 20ug, 50ug

Applications: Others(N/A)

Mol. Wt.: 16

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.