bs-10743R-BF488 [Conjugated Primary Antibody]
Caspase-1 p20 Polyclonal Antibody, AbBy Fluor® 488 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Caspase-1 p20

Immunogen Range: 101-200/404


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 834

Swiss Prot: P29466

Source: KLH conjugated synthetic peptide derived from human Caspase-1 p20

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Conjugation: AbBy Fluor® 488

Excitation/ Emission: 499nm/519nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 20/46


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Bian X et al. Periostin contributes to renal and cardiac dysfunction in rats with chronic kidney disease: reduction of PPARα.Biochimie. 2019 May;160:172-182.Read more>>
  • Zhao J et al. Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling. Biomed Pharmacother. 2020 Jul;127:110151.Read more>>
  • Adrianne F. Pike. et al. \Synuclein evokes NLRP3 inflammasome\mediated IL\1 secretion from primary human microglia. Glia. 2021 Jan 28Read more>>
  • Cheng Quancheng. et al. Aquaporin 9 Represents a Novel Target of Chronic Liver Injury That May Antagonize Its Progression by Reducing Lipotoxicity. Oxid Med Cell Longev. 2021;2021:56537Read more>>
  • Xiaohui Wang. et al. Short-wavelength blue light contributes to the pyroptosis of human lens epithelial cells (hLECs). Exp Eye Res. 2021 Nov;212:108786Read more>>
  • Shi, Chenxi. et al. Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 inflammasome. Vet Res. 2022 Dec;53(1):1-16Read more>>
  • Xuliang Zhang. et al. PINK1/Parkin-mediated mitophagy mitigates T-2 toxin-induced nephrotoxicity. FOOD CHEM TOXICOL. 2022 Jun;164:113078Read more>>
  • Yingchun Luo. et al. Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis. EBIOMEDICINE. 2022 Aug;82:104087Read more>>
  • Yunzhu Yang. et al. Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/autophagy/NLRP3 signal axis in fibrillar A-activated microglia. BRAIN RES. 2023 Feb;1801:148206Read more>>
  • Xiang Wu. et al. NLRP3 inflammasome inhibitor MCC950 reduces cerebral ischemia/reperfusion induced neuronal ferroptosis. NEUROSCI LETT. 2023 Jan;795:137032Read more>>
  • Peng, Xin. et al. A20 ameliorates disc degeneration by suppressing mTOR/BNIP3 axis-mediated mitophagy. GENES GENOM. 2022 Dec;:1-15Read more>>
  • Jiajun Chen. et al. Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism. J PHARM ANAL. 2023 AugRead more>>
  • Huimin Yuan. et al. NLRP3 neuroinflammatory intervention of Mahuang-Lianqiao-Chixiaodou decoction for mental disorders in atopic dermatitis mice. J ETHNOPHARMACOL. 2023 Sep;:117263Read more>>
VALIDATION IMAGES