bs-10879P
[Protein]
Recombinant human NT-proBNP protein, N-His
DATASHEET
Entrez Gene: 4879
Swiss Prot: P16860
Source: Recombinant human NT-proBNP protein, N-His protein is expressed in E.coli with N-His. It contains the amino acid sequence of 27-102/134.
Storage Buffer: 0.01M TBS(pH7.4)
Storage: The product should be stored at -70°C or -20°C.
Background:
Brain natriuretic peptide (BNP), also known as B-type natriuretic peptide, is a hormone secreted by cardiomyocytes in the heart ventricles in response to stretching caused by increased ventricular blood volume.
The 32-amino acid polypeptide BNP is secreted attached to a 76鈥揳mino acid N-terminal fragment in the prohormone called NT-proBNP (BNPT), which is biologically inactive. Once released, BNP binds to and activates the atrial natriuretic factor receptor NPRA, and to a lesser extent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) but with 10-fold lower affinity. The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better targets than ANP for diagnostic blood testing.
The 32-amino acid polypeptide BNP is secreted attached to a 76鈥揳mino acid N-terminal fragment in the prohormone called NT-proBNP (BNPT), which is biologically inactive. Once released, BNP binds to and activates the atrial natriuretic factor receptor NPRA, and to a lesser extent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) but with 10-fold lower affinity. The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better targets than ANP for diagnostic blood testing.
Size: 100ug,500ug
Applications: ELISA()
Mol. Wt.: 9.3
Species: Others
For research use only. Not intended for diagnostic or therapeutic use.