KLH conjugated synthetic peptide derived from human ProSAPiP1
Purified by Protein A.
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
The ProSAP family of proteins contain many protein-protein interaction domains and serve as scaffolding mediators within the post-synaptic density (PSD) of excitatory brain synapses. The PSD is an electron-dense structure underneath the post-synaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the pre-synaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localization of ion channels, receptors, signaling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). ProSAPiP1 (proline rich synapse associated protein interacting protein 1) is a 673 amino acid protein that interacts with the PDZ domain of Shank 3. ProSAPiP1 expression is brain-specific with highest expression within the cerebellum, hippocampus and cerebral cortex.
PRODUCT SPECIFIC PUBLICATIONS
- Liyang Tong. et al. Topical bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF\1 protein in young rabbits. Ophthal Physl Opt. 2020 Sep;40(5):567-576Read more>>
Formalin-fixed and paraffin embedded rat brain labeled with Anti-ProSAPiP1 Polyclonal Antibody, Unconjugated (bs-11198R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Lane 1: Mouse Eye lysates probed with ProSAPiP1 Polyclonal Antibody, Unconjugated (bs-11198R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.