bs-11219R-A750

DATASHEET

Host: Rabbit

Target Protein: Exportin 5

Immunogen Range: 221-320/1204

Clonality: Polyclonal

Isotype: IgG

Source: KLH conjugated synthetic peptide derived from human Exportin 5

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Exportin 5 (XPO5) is a member of the importin _ family of proteins and functions in tRNA export in a sequence dependent fashion. More recently, it has been shown to export pre-miRNA by a RanGTPase-driven process from the nucleus to the cytoplasm, where pre-miRNA processing occurs to produce mature miRNAs. Study of the miRNA biosynthesis pathway is essential in understanding the process of oncogenesis as global downregulation of miRNAs and the resulting alterations in the expression of tumor suppressor and oncogenic proteins is a common phenotype of cancers cells . Research studies have shown disruption of exportin 5 functions in many types of cancers including breast and lung, where pre-miRNA accumulates in the nucleus and miRNA maturation is impaired.

Conjugation: ALEXA FLUOR® 750

Excitation/ Emission: 749nm/775nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 136

Cross Reactive Species: Mouse

Predicted Cross Reactive Species: Human
Rat
Dog
Cow
Sheep
Pig
Horse
Chicken
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.