bs-1125R [Primary Antibody]
5-HTR1B Polyclonal Antibody
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Host: Rabbit

Target Protein: 5-HTR1B

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3351

Source: KLH conjugated synthetic peptide derived from human 5-HTR1B

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009].

Size: 100uL

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IHC-P(1:200-400)
IF(IHC-P)(1:50-200)

Cross Reactive Species: Human
Mouse
Rat
Bovine
Dog
Pig
Chicken

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Sun, Tao, et al. "Antihypertensive effect of formononetin through regulating the expressions of eNOS, 5-HT< sub> 2A/1B</sub> receptors and ??< sub> 1</sub>-adrenoceptors in spontaneously hypertensive rat arteries."European journal of pharmacology (2013)..Read more>>
  • Liu et al. Fluoxetine attenuates chronic methamphetamine-induced pulmonary arterial remodelling: possible involvement of serotonin transporter and serotonin 1B receptor. (2013) Basic.Clin.Pharmacol.Toxicol. 112:77-82Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded rat brain (snr) labeled with Anti-5-HTR1B Polyclonal Antibody, Unconjugated (bs-1125R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.


Lane 1: Mouse Cerebrum tissue lysates; Lane 2: Rat Placenta tissue lysates; Lane 3: Rat Cerebrum tissue lysates probed with 5HT1B Receptor Polyclonal Antibody, Unconjugated (bs-1125R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at room temperature for 60 min.