bs-1138R [Primary Antibody]
SSTR2/Somatostatin Receptor 2 Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: SSTR2/Somatostatin Receptor 2

Immunogen Range: 211-320/369


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6752

Swiss Prot: P30874

Source: KLH conjugated synthetic peptide derived from human SSTR2

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)

Predicted Molecular Weight: 41


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat
Dog
Cow
Pig
Horse
Chicken
Rabbit
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Ruan, Ming, et al. "Attenuation of stress-induced gastrointestinal motility disorder by gentiopicroside, from Gentiana macrophylla Pall." Fitoterapia(2015).Read more>>
  • Sakai, Kosei, et al. "Alteration of somatostatin receptor 2 expression in canine mammary gland tumor." Journal of Veterinary Medical Science 0 (2015).Read more>>
  • Zhao D et al. PCB52 exposure alters the neurotransmission ligand-receptors in male offspring and contributes to sex-specific neurodevelopmental toxicity. Environ Pollut.2020 Sep;264:114715.Read more>>
  • Jiuxiu Jiet al. The effect of miR\10b on growth hormone in pituitary cells of Yanbian yellow cattle by somatostatin receptor 2. Anim Sci J. Jan-Dec 2020;91(1):e13420.Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded mouse lung tissue labeled with Anti-SSTR2 Polyclonal Antibody, Unconjugated (bs-1138R) followed by conjugation to the secondary antibody and DAB staining