bs-1178R-A680 [Conjugated Primary Antibody]
PAR-2 Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated
www.biossusa.com
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DATASHEET

Host: Rabbit

Target Protein: PAR-2

Immunogen Range: 101-150/397


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2150

Swiss Prot: P55085

Source: KLH conjugated synthetic peptide derived from human PAR2

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]

Conjugation: ALEXA FLUOR® 680

Excitation/ Emission: 679nm/702nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 40


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Chao G et al. Teprenone ameliorates diclofenac-induced small intestinal injury via inhibiting protease activated receptors 1 and 2 activityBiomarkers.2021 Feb;26(1):38-44.Read more>>
  • Hideki Imano. et al. Rivaroxaban Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Hypertension. 2021 Feb 2Read more>>
  • Yan Luo. et al. Effects of norepinephrine on colonic tight junction protein expression during heat stress. Exp Ther Med. 2021 May;21(5):1-9Read more>>
  • Hiroko Habuchi. et al. Bone marrow derived mast cells injected into the osteoarthritic knee joints of mice induced by sodium monoiodoacetate enhanced spontaneous pain through activation of PAR2 and action of extracellular ATP. Plos One. 2021 Jun;16(6):e025259Read more>>
  • Qian Zhang. et al. Rivaroxaban, a direct inhibitor of coagulation factor Xa, attenuates adverse cardiac remodeling in rats by regulating the PAR-2 and TGF-1 signaling pathways. PEERJ. 2023 Sep;11:e16097Read more>>
VALIDATION IMAGES