DATASHEET
Host:
Rabbit
Target Protein:
NRG1
Immunogen Range:
81-200/640
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
3084
Swiss Prot:
Q02297
Source:
KLH conjugated synthetic peptide derived from human Neuregulin-1
Purification:
Purified by Protein A.
Storage Buffer:
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). The NRG-1 protein binds to and activates the tyrosine kinases receptors ErbB3 and ErbB4, initiating signaling cascades. NRG-1 has multiple functions; for example, in the brain it regulates various processes such as radial glia formation and neuronal migration, dendritic development, and expression of neurotransmitters receptors; in the peripheral nervous system NRG-1 regulates processes such as target cell differentiation, and Schwann cell survival.
Conjugation:
Cy5
Excitation/ Emission:
625,650nm/670nm
Size:
100ul
Concentration:
1ug/ul
Applications:
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
24/68
Rat
Predicted Cross Reactive Species:
Human
Mouse
Cow
Sheep
Horse
Rabbit
For research use only. Not intended for diagnostic or therapeutic use.