DATASHEET
Host:
Rabbit
Target Protein:
Il23a
Immunogen Range:
101-196/196
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
51561
Swiss Prot:
Q9NPF7
Source:
KLH conjugated synthetic peptide derived from human Il23a
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Background:
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
PRODUCT SPECIFIC PUBLICATIONS
- Yang, Xiao, et al. "Effect of Iodine Excess on Th1, Th2, Th17, and Treg Cell Subpopulations in the Thyroid of NOD. H-2h4 Mice." Biological Trace Element Research (2014): 1-9.Read more>>
- Sun, Jiabing, et al. "A Crucial Role of IL-17 in Bone Resorption During Rejection of Fresh Bone Xenotransplantation in Rats." Cell Biochemistry and Biophysics: 1-7.Read more>>
- Wang, Mingfei, et al. "Damage effect of Interleukin (IL)-23 on oxygen-glucose deprived cells of the neurovascular unit via IL-23 receptor." Neuroscience (2015).Read more>>
- Qiu et al. Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat. (2018) J.Immunol.Res. 2018:2952471Read more>>
- Zhang Q et al. Transcriptome Analysis of the Gene Expression Profiles Associated with Fungal Keratitis in Mice Based on RNA-Seq. Invest Ophthalmol Vis Sci. 2020 Jun 3;61(6):32.Read more>>
- Qi Yin. et al. An immuno-blocking agent targeting IL-1 and IL-17A reduces the lesion of DSS-induced ulcerative colitis in mice. 2021 Apr 2Read more>>
- Tin-Yun Ho. et al. Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition on interleukin-17A/interleukin-17A receptor interaction. FOOD FUNCT. 2022 MayRead more>>
- Feng Huang. et al. NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice. J ETHNOPHARMACOL. 2023 Jan;300:115626Read more>>
- Wei WANG. et al. Anti-psoriasis molecular targets and active components discovery of Optimized Yinxieling Formula via affinity-purified strategy. CHIN J NAT MEDICINES. 2024 Feb;22:127Read more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded human rhinopolypus labeled with Rabbit Anti IL-23 Polyclonal Antibody, Unconjugated (bs-1193R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Lane 1: Mouse Ear tissue lysates; Lane 2: Human A431 cell lysates; Lane 3: Human Jurkat cell lysates probed with IL-23 Polyclonal Antibody, Unconjugated (bs-1193R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.