bs-1193R-A350 [Conjugated Primary Antibody]
Il23a Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Il23a

Immunogen Range: 101-196/196


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 51561

Swiss Prot: Q9NPF7

Source: KLH conjugated synthetic peptide derived from human Il23a

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Conjugation: ALEXA FLUOR® 350

Excitation/ Emission: 346nm/442nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)

Predicted Molecular Weight: 21


Cross Reactive Species: Human
Rat

Predicted Cross Reactive Species: Mouse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yang, Xiao, et al. "Effect of Iodine Excess on Th1, Th2, Th17, and Treg Cell Subpopulations in the Thyroid of NOD. H-2h4 Mice." Biological Trace Element Research (2014): 1-9.Read more>>
  • Sun, Jiabing, et al. "A Crucial Role of IL-17 in Bone Resorption During Rejection of Fresh Bone Xenotransplantation in Rats." Cell Biochemistry and Biophysics: 1-7.Read more>>
  • Wang, Mingfei, et al. "Damage effect of Interleukin (IL)-23 on oxygen-glucose deprived cells of the neurovascular unit via IL-23 receptor." Neuroscience (2015).Read more>>
  • Qiu et al. Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat. (2018) J.Immunol.Res. 2018:2952471Read more>>
  • Zhang Q et al. Transcriptome Analysis of the Gene Expression Profiles Associated with Fungal Keratitis in Mice Based on RNA-Seq. Invest Ophthalmol Vis Sci. 2020 Jun 3;61(6):32.Read more>>
  • Qi Yin. et al. An immuno-blocking agent targeting IL-1 and IL-17A reduces the lesion of DSS-induced ulcerative colitis in mice. 2021 Apr 2Read more>>
  • Tin-Yun Ho. et al. Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition on interleukin-17A/interleukin-17A receptor interaction. FOOD FUNCT. 2022 MayRead more>>
  • Feng Huang. et al. NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice. J ETHNOPHARMACOL. 2023 Jan;300:115626Read more>>
  • Wei WANG. et al. Anti-psoriasis molecular targets and active components discovery of Optimized Yinxieling Formula via affinity-purified strategy. CHIN J NAT MEDICINES. 2024 Feb;22:127Read more>>
VALIDATION IMAGES