bs-1198R-PerCP [Conjugated Primary Antibody]
HLA-DR Polyclonal Antibody, PerCP Conjugated
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Host: Rabbit

Target Protein: HLA-DR

Immunogen Range: 30-80/254


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3122

Swiss Prot: P01903

Source: KLH conjugated synthetic peptide derived from human HLA-DRA

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]

Conjugation: PerCP

Excitation/ Emission: 482nm/677nm

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:1000-5000)
IF(1:500-2000)

Predicted Molecular Weight: 29


Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Solhaug, A., et al. "The mycotoxin alternariol induces DNA damage and modify macrophage phenotype and inflammatory responses." Toxicology Letters(2015).Read more>>
  • Gao et al. Common expression of stemness molecular markers and early cardiac transcription factors in human Wharton's jelly-derived mesenchymal stem cells and embryonic stem cells. (2013) Cell.Transplan. 22:1883-900Read more>>
  • Oh et al. Analysis of macrophage phenotype in rejected corneal allografts. (2013) Invest.Ophthalmol.Vis.Sc. 54:7779-84Read more>>
  • Zhang C et al. CXCR4-Overexpressing Umbilical Cord Mesenchymal Stem Cells Enhance Protection against Radiation-Induced Lung Injury. Stem Cells Int. 2019 Feb 5;2019:2457082. Read more>>
  • Kitala D et al. Amniotic cells share clusters of differentiation of fibroblasts and keratinocytes, influencing their ability to proliferate and aid in wound healing while impairing their angiogenesis capability.Eur J Pharmacol. 2019 Feb 28;854:167-178.Read more>>
  • Liu S et al. Structural characterization of a novel polysaccharide from Panax notoginseng residue and its immunomodulatory activity on bone marrow dendritic cells. Int J Biol Macromol. 2020 Oct 15;161:797-809.Read more>>
  • Diana Kitala. et al. Application of Amniotic Stem Cells on an Acellular Dermal Matrix Scaffold in a Burned Patient: A Case Report. Transpl P. 2020 Oct;52:2563Read more>>
  • Zhe Wang. et al. Hypoxia Protects Rat Bone Marrow Mesenchymal Stem Cells Against Compression-Induced Apoptosis in the Degenerative Disc Microenvironment Through Activation of the HIF-1/YAP Signaling Pathway. Stem Cells Dev. 2020 Oct;29(20):1309-1319Read more>>
  • Jingchuan Sun. et al. Long noncoding RNA AC092155 facilitates osteogenic differentiation of adipose-derived stem cells through the miR-143-3p/STMN1 axis. 2021 May 15Read more>>
  • Jinsheng Li. et al. Micro/nano-topography Promotes Osteogenic Differentiation of Bone Marrow Stem Cells by Regulating Periostin Expression. COLLOID SURFACE B. 2022 Jul;:1127Read more>>
VALIDATION IMAGES