bs-1207R [Primary Antibody]
GLUT3 Polyclonal Antibody
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Host: Rabbit

Target Protein: GLUT3

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6515

Source: KLH conjugated synthetic peptide derived from human GLUT3

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

may act as a glucose transporter in neurons; may mediate increasd glucose uptake in response to neuronal injury. Glucose is fundamental to the metabolism of mammalian cells. Several glucose transporter protein (Glut) isoforms have been identified and shown to function in response to insulin and IGF1 induced signaling. GLUT3 is detectable in a few normal cell type spermatids in testis with active spermatogenesis, placental trophoblast membranes, and neurons in brain. GLUT3 staining is also detectable in human cancers including those of the ovary, lung, and testis. Alternative names: FLJ90380; Glucose Transporter Type 3; Glucose transporter type 3 brain; GLUT 3; GLUT3; SLC2A3; Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3.

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:50-200)
IHC-P(1:200-400)
IF(IHC-P)(1:300-5000)

Cross Reactive Species: Human
Mouse
Rat
Bovine
Dog
Pig
Chicken

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yan, Yu-E., et al. ʺSignificant Reduction of the GLUT3 Level, but not GLUT1 Level, Was Observed in the Brain Tissues of Several Scrapie Experimental Animals and Scrapie-Infected Cell Lines.ʺ Molecular neurobiology (2013): 1-14.Read more>>
  • Yun S et al. Effects of lead exposure on brain glucose metabolism and insulin signaling pathway in the hippocampus of rats. Toxicol Lett. 2019 Aug;310:23-30.Read more>>
  • Hu C et al. Placentae for Low Birth Weight Piglets Are Vulnerable to Oxidative Stress, Mitochondrial Dysfunction, and Impaired Angiogenesis. Oxid Med Cell Longev. 2020 May 25;2020:8715412.Read more>>
  • Zhao, Ying. et al. Apigenin increases radiosensitivity of glioma stem cells by attenuating HIF-1-mediated glycolysis. Med Oncol. 2021 Nov;38(11):1-1Read more>>
  • Huang, Hui. et al. Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3/AMPK/mTOR pathway-controlled glycolysis. N-S ARCH PHARMACOL. 2022 Nov;:1-1Read more>>
  • Ziyi Zhong. et al. Tumor-associated macrophages drive glycolysis through the IL-8/STAT3/GLUT3 signaling pathway in pancreatic cancer progression. CANCER LETT. 2024 Apr;588:216784Read more>>
  • Li Yating. et al. Neonatal vitamin A supplementation improves sheep fertility potential. FRONT VET SCI. 2024 May;11Read more>>
  • Cui-ling Jia. et al. Rosmarinic acid Liposomes Suppress Ferroptosis in Ischemic Brain via Inhibition of TfR1 in BMECs. PHYTOMEDICINE. 2024 Jun;:155835Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-GLUT3 Polyclonal Antibody, Unconjugated (bs-1207R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.


Formalin-fixed and paraffin embedded rat brain labeled with Anti GLUT3 Polyclonal Antibody, Unconjugated (bs-1207R) at 1:200 followed by secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated (bs-0295G-Cy3) used at 1:200 dilution for 40 minutes at 37°C


Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti Glut3 Polyclonal Antibody, FITC conjugated (bs-1207R-FITC) 1:100, 60 minutes at 37°C


L1 human colon carcinoma lysates L2 mouse kidney lysates probed with Anti GLUT3 Polyclonal Antibody, Unconjugated (bs-1207R) at 1:200 overnight at 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 for 90 min at RT. Predicted band 54kD. Observed band size:54kD.