bs-1215R-A555 [Conjugated Primary Antibody]
Trptophan Hydroxylase Antibody, ALEXA FLUOR® 555 Conjugated
www.biossusa.com
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DATASHEET

Host: Rabbit

Target Protein: Tryptophan 5-hydroxylase 1, Tryptophan 5-hydroxylase 2

Immunogen Range: 31-150/444


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 7166

Swiss Prot: P17752

Source: KLH conjugated synthetic peptide derived from human Tryptophan 5-hydroxylase 1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].

Conjugation: ALEXA FLUOR® 555

Excitation/ Emission: 555nm/580nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 49


Cross Reactive Species: Human
Mouse
Rat
Others

Predicted Cross Reactive Species: Dog
Horse
Chicken
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Dong, Xian-Zhe, et al. "A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive Rats." Journal of Ethnopharmacology (2013).Read more>>
  • Tian L et al. Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems. J Nat Med. 2019 Nov 25. Read more>>
  • Ryo Kajihara. et al. Water intake releases serotonin from enterochromaffin cells in rat jejunal villi. 2021 Apr 28Read more>>
  • aba, Kazuhiko. et al. Upregulation of the hypothalamo-neurohypophysial system and activation of vasopressin neurones attenuates hyperalgesia in a neuropathic pain model rat. SCI REP-UK. 2022 Jul;12(1):1-15Read more>>
  • Lei Wu. et al. Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway. FOODS. 2023 Jan;12(5):1101Read more>>
  • Naofumi Ikeda. et al. Chemogenetic Activation of Oxytocin Neurons Improves Pain in a Reserpine-induced Fibromyalgia Rat Model. NEUROSCIENCE. 2023 JulRead more>>
  • Deng Rui. et al. Capsaicin orchestrates metastasis in gastric cancer via modulating expression of TRPV1 channels and driving gut microbiota disorder. CELL COMMUN SIGNAL. 2023 Dec;21(1):1-18Read more>>
VALIDATION IMAGES