bs-12359R [Primary Antibody]
DMP1 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: DMP1

Immunogen Range: 221-320/513


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1758

Source: KLH conjugated synthetic peptide derived from human DMP1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

DMP-1 is a member of the small integrin ligand N-linked glycoprotein family. It is important for the mineralization of bone and dentin. DMP-1 is expressed in bone, tooth and hypertrophic cartilage. It is synthesized by preosteoblasts and contains a large number of acidic domains. DMP-1 localizes to the nucleus of undifferentiated osteoblasts where it functions as a transcriptional regulator for osteoblast-specific gene activation and induces osteoblast differentiation. During osteoblast maturation, DMP-1 undergoes a conformational change and becomes phosphorylated by casein kinase II in response to an influx of calcium ions to the nucleus. DMP-1 is then exported to the extracellular matrix (ECM) where it regulates the nucleation of hydroxyapatite and the formation of calcified tissue. DMP-1 is proteolytically processed into N- and C-terminal fragments in the ECM of bone and dentin. The protein has also been identified in bone as a high molecular weight proteoglycan comprised of the N-terminal DMP-1 fragment and chondroitin sulfate.The loss of DMP-1 can result in hypomineralized bone.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
ICC(1:100-500)

Predicted Molecular Weight: 54


Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Zhan, Fu‐Liang, Xin‐Yang Liu, and Xing‐Bo Wang. "The Role of MicroRNA‐143‐5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting Runx2 via the OPG/RANKL Signaling Pathway." Journal of Cellular Biochemistry (2017).Read more>>
  • Zhan et al. The Role of MicroRNA-143-5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting Runx2 via the OPG/RANKL Signaling Pathway. (2018) J.Cell.Biochem. 119:536-546Read more>>
  • "Chen X et al. Modulation of proliferation and differentiation of gingiva‑derived mesenchymal stem cells by concentrated growth factors: Potential implications in tissue engineering for dental regeneration and repair. Send to Int J Mol Med. 2019 Apr 24. "Read more>>
  • Sun N et al. Graphene oxide-coated porous titanium for pulp sealing: an antibacterial and dentino-inductive restorative material. J Mater Chem B. 2020 Jul 8;8(26):5606-5619.Read more>>
  • Chao Wang. et al. SFRP2 enhances dental pulp stem cell\mediated dentin regeneration in rabbit jaw. 2020 Nov 08Read more>>
  • Zheng, Han. et al. miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition. Int J Oral Sci. 2021 Dec;13(1):1-1Read more>>
  • Ning Wang. et al. miR-6807-5p Inhibited the Odontogenic Differentiation of Human Dental Pulp Stem Cells Through Directly Targeting METTL7A. Front Cell Dev Biol. 2021; 9: 759192Read more>>
  • Jingzhi Li. et al. TGF-_2 and TGF-_1 differentially regulate the odontogenic and osteogenic differentiation of mesenchymal stem cells. Arch Oral Biol. 2022 Mar;135:105357Read more>>
  • K?KKAYA EREN Selen. et al. Combined effects of bone morphogenetic protein-7 and mineral trioxide aggregate on the proliferation, migration, and differentiation of human dental pulp stem cells. J APPL ORAL SCI. 2022 Sep;3Read more>>
  • Nan Wang. et al. Histological analysis of pulp mineralisation after severe intrusive luxation of immature molars in rats. DENT TRAUMATOL. 2023 FebRead more>>
  • Luo Bin. et al. Residual periodontal ligament in the extraction socket promotes the dentin regeneration potential of DPSCs in the rabbit jaw. STEM CELL RES THER. 2023 Dec;14(1):1-14Read more>>
  • Yanmei Wang. et al. Involvement of Dmp1 in the Precise Regulation of Hair Bundle Formation in the Developing Cochlea. BIOLOGY-BASEL. 2023 Apr;12(4):625Read more>>
  • Luo Xinghong. et al. Odontoblasts release exosomes to regulate the odontoblastic differentiation of dental pulp stem cells. STEM CELL RES THER. 2023 Dec;14(1):1-16Read more>>
  • Haoqing Yang. et al. miR615-3p inhibited FBLN1 and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m6A-miRNA interaction manner. CELL PROLIFERAT. 2024 Feb;:e13607Read more>>