bs-12503R-PE

DATASHEET

Host: Rabbit

Target Protein: APPBP1

Immunogen Range: 401-500/534

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 8883

Swiss Prot: Q13564

Source: KLH conjugated synthetic peptide derived from human APPBP1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

Conjugation: PE

Excitation/ Emission: 496,564nm/578nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)

Predicted Molecular Weight: 60

Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Dog
Pig
Horse
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.