bs-12702R-HRP [Conjugated Primary Antibody]
DRP1 (Ser616) Polyclonal Antibody, HRP Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: DRP1 (Ser616)

Modification Site: Ser616

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 10059

Swiss Prot: O00429

Source: KLH conjugated synthesised phosphopeptide derived from human DRP1 around the phosphorylation site of Ser616

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)

Predicted Molecular Weight: 82


Cross Reactive Species: Mouse

Predicted Cross Reactive Species: Human
Rat
Dog
Pig
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Guo J et al. Drp1 mediates high glucose-induced mitochondrial dysfunction and epithelial-mesenchymal transition in endometrial cancer cells. Exp Cell Res. 2020 Feb 1:111880.Read more>>
  • Lei, Xinyuan. et al. Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression. NAT COMMUN. 2022 Jul;13(1):1-16Read more>>
VALIDATION IMAGES