Target Protein: Frizzled 10/CD350
Specificity: Due to the similarity of this protein to Frizzled 9, there is a chance that this antibody will react with this protein based on homology.
Immunogen Range: 100-150/581
Entrez Gene: 11211
Swiss Prot: Q9ULW2
Source: KLH conjugated synthetic peptide derived from human Frizzled 10/CD350
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.